Secretion of locally synthesized neurohormone from neurites of peptidergic neurons
Secretion of locally synthesized neurohormone from neurites of peptidergic neurons
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肽能神经元神经突分泌局部合成的神经激素
DOI：
10.1046/j.1471-4159.2003.02194.x
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发表时间：
2003
影响因子：
4.7
通讯作者：
N. Wayne
中科院分区：
文献类型：
--
作者：
Wenjau Lee;N. Wayne
Local protein synthesis in neuronal processes is a common phenomenon and may play an important role in synaptic plasticity and hormonal regulation. We have used neuroendocrine bag cells of Aplysia californica as a model system to study local protein synthesis. In our previous work we found that bag cell neurites are capable of synthesizing and processing the prohormone of egg‐laying hormone (pro‐ELH). In the present study, we found that bag cell neurites are also capable of releasing locally synthesized pro‐ELH and ELH‐related products via both constitutive and regulated pathways. However, an electrical afterdischarge did not enhance local pro‐ELH synthesis, as it does in the bag cell soma. This is the first evidence that isolated neurites are capable of secreting locally synthesized proteins.
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DOI：
10.1210/endo.139.12.6350
发表时间：
1998
期刊：
Endocrinology.
影响因子：
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作者：
Lee,W;Wayne,NL
通讯作者：
Wayne,NL
DOI：
10.1002/neu.10242
发表时间：
2003-09-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
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作者：
Liu, K;Hu, JY;Schacher, S
通讯作者：
Schacher, S
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影响因子：
4.8
作者：
Wayne,NL;Wong,H
通讯作者：
Wong,H
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DOI：
10.1006/gcen.1997.6916
发表时间：
1997
期刊：
General and comparative endocrinology.
影响因子：
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作者：
Lee,W;Wayne,NL
通讯作者：
Wayne,NL