Histamine-2 Receptor Blockers Alter the Fecal Microbiota in Premature Infants
Histamine-2 Receptor Blockers Alter the Fecal Microbiota in Premature Infants
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DOI：
10.1097/mpg.0b013e318282a8c2
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发表时间：
2013-04-01
影响因子：
2.9
通讯作者：
Penn, Duna
中科院分区：
文献类型：
--
作者：
Gupta, Raegan W.;Lynn Tran;Penn, Duna
目的：细菌定植被认为是坏死性小肠结肠炎（NEC）的主要危险因素。本研究的目的是通过使用敏感的分子生物学技术分析和比较接受和不接受H2受体阻滞剂治疗的早产儿的粪便微生物群来验证组胺-2受体（H2-）阻滞剂改变结肠细菌定植的假设。
Objectives: Bacterial colonization is considered a major risk factor for necrotizing enterocolitis (NEC). The objective of the present study was to test the hypothesis that histamine-2 receptor (H2-) blockers alter colonic bacterial colonization by analyzing and comparing the fecal microbiota in premature infants with and without H2-blocker therapy using sensitive molecular biological techniques.Methods: Seventy-six premature infants