Inflammation as a cause of functional bowel disorders
Inflammation as a cause of functional bowel disorders
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DOI：
10.1080/00365520510023657
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发表时间：
2005-10-01
影响因子：
1.9
通讯作者：
Öhman, L
中科院分区：
文献类型：
--
作者：
Törnblom, H;Abrahamsson, H;Öhman, L
本文讨论了炎症作为功能性肠病（FBD）的原因。炎症似乎在FBD中发挥重要作用，迄今为止研究最多的病症是肠易激综合征（IBS）。肥大细胞作为IBS症状的可能原因继续受到关注，因为它们的强效促炎成分可以改变神经和平滑肌功能。大量患者在急性感染性胃肠炎发作后出现持续性IBS症状的观察结果可以被认为是免疫介导机制如何在IBS发病机制中发挥作用的原型实例。
The article presents a discussion on inflammation as a cause of functional bowel disorders (FBD). Inflammation does appear to play an important role in FBD, so far the most investigated condition is irritable bowel syndrome (IBS). Mast cells have continued to gain attention as a possible cause of IBS symptoms because of their potent pro-inflammatory content that can alter both neural and smooth-muscle function. The observation that a great many patients develop persistent IBS symptoms after an acute bout of infectious gastroenteritis can be considered a prototype example of how immune-mediated mechanisms play a role in the pathogenesis of IBS.