Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants
Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants
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DOI：
10.1016/j.chemosphere.2010.07.023
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发表时间：
2010-09-01
期刊：
影响因子：
8.8
通讯作者：
Tanaka, Hiroaki
中科院分区：
文献类型：
--
作者：
Ghosh, Gopal Chandra;Nakada, Norihide;Tanaka, Hiroaki
我们调查了2008-2009年和2009-2010年日本流感季节期间三个污水处理厂（STP）中两种抗病毒药物羧酸奥司他韦（OC）（达菲的活性代谢产物）和金刚烷胺（AMT）的发生和转归。在分析的所有样品中均检测到这两种化合物。在STPs的原始流入物中的浓度范围为140至460 ng L-1 OC和184至538 ng L-1 AMT。初步治疗没有实质性清除药物（OC，2-9%; AMT，7-17%）。基于生物脱氮的二级处理（缺氧-好氧-缺氧-好氧和厌氧-缺氧-好氧）去除了20-37%的OC，而基于延长曝气的常规活性污泥处理去除了20-37%的OC。
We investigated the occurrence and fate of the two antiviral drugs oseltamivir carboxylate (OC) the active metabolite of Tamiflu and amantadine (AMT) at three sewage treatment plants (STPs) during the 2008-2009 and 2009-2010 influenza seasons in Japan. Both compounds were detected in all samples analyzed. The concentrations in raw influents at the STPs ranged from 140 to 460 ng L-1 OC and from 184 to 538 ng L-1 AMT. Primary treatment gave no substantial removal of the drugs (OC, 2-9%; AMT, 7-17%). Biological nutrient-removal-based secondary treatment (anoxic-oxic-anoxic-oxic and anaerobic-anoxic-oxic) removed 20-37% of OC, whereas extended-aeration-based conventional activated sludge treatment removed