The human amygdala is sensitive to the valence of pictures and sounds irrespective of arousal: an fMRI study
The human amygdala is sensitive to the valence of pictures and sounds irrespective of arousal: an fMRI study
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DOI：
10.1093/scan/nsn017
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发表时间：
2008-09-01
影响因子：
4.2
通讯作者：
Veit, Ralf
中科院分区：
文献类型：
--
作者：
Anders, Silke;Eippert, Falk;Veit, Ralf
随着研究的到来，杏仁核的反应并不局限于恐惧相关或非常令人不快的刺激，研究开始专注于刺激价格和刺激相关的唤醒作为杏仁核活动的预测因子。最近在化学感觉领域的研究发现，杏仁核的活动随着负和正化学感觉刺激的强度而增加。这导致了杏仁核活动可能是情绪唤醒的指示器的提议，至少在化学感觉领域是这样。本研究调查了杏仁核对视觉和听觉刺激的反应。通过根据个体效价和唤醒等级来选择刺激，我们能够在言语和外周生理水平上分离刺激效价和刺激相关的唤醒。我们发现，即使在控制了唤醒的情况下，杏仁核对刺激价也很敏感，而且杏仁核活动的增加可以更好地用刺激价而不是唤醒来解释。杏仁核活动和刺激相关的觉醒之间的关系在化学感觉和视听领域之间的关系的提出的差异，从杏仁核嵌入这些感觉系统和获得情绪意义的过程的角度进行了讨论。
With the advent of studies showing that amygdala responses are not limited to fear-related or highly unpleasant stimuli, studies began to focus on stimulus valence and stimulus-related arousal as predictors of amygdala activity. Recent studies in the chemosensory domain found amygdala activity to increase with the intensity of negative and positive chemosensory stimuli. This has led to the proposal that amygdala activity might be an indicator of emotional arousal, at least in the chemosensory domain. The present study investigated amygdala activity in response to visual and auditory stimuli. By selecting stimuli based on individual valence and arousal ratings, we were able to dissociate stimulus valence and stimulus-related arousal, both on the verbal and the peripheral physiological level. We found that the amygdala was sensitive to stimulus valence even when arousal was controlled for, and that increased amygdala activity was better explained by valence than by arousal. The proposed difference in the relation between amygdala activity and stimulus-related arousal between the chemosensory and the audiovisual domain is discussed in terms of the amygdalas embedding within these sensory systems and the processes by which emotional meaning is derived.