Dendritic cells prime natural killer cells by trans-presenting interleukin 15
Dendritic cells prime natural killer cells by trans-presenting interleukin 15
复制标题
DOI：
10.1016/j.immuni.2007.03.006
复制
发表时间：
2007-04-01
期刊：
影响因子：
32.4
通讯作者：
Diefenbach, Andreas
中科院分区：
文献类型：
--
作者：
Lucas, Mathias;Schachterle, William;Diefenbach, Andreas
自然杀伤（NK）细胞是控制感染的重要效应细胞。体内NK细胞活化所需的细胞和分子信号仍然不清楚。通过使用小鼠模型的树突状细胞（DC）的诱导消融，我们表明，在体内引发的NK细胞对病毒和细菌病原体的反应需要的CD 11 c（高）DC的存在。外周Toll样受体（TLR）刺激后，NK细胞被募集到局部淋巴结，它们与DC的相互作用导致外周出现效应NK细胞。NK细胞启动依赖于DC对I型IFN信号的识别;以及随后DC向静息NK细胞产生和反式呈递IL-15。CD 11 c（高）DC衍生的IL-15是必要的，足以引发NK细胞。我们的数据定义了一个独特的在体内的作用，树突状细胞的引发NK细胞，揭示了一个惊人的和以前不受重视的同源性，T淋巴细胞的适应性免疫系统。
Natural killer (NK) cells are important effector cells in the control of infections. The cellular and molecular signals required for NK cell activation in vivo remain poorly defined. By using a mouse model for the inducible ablation of dendritic cells (DCs), we showed that the in vivo priming of NK cell responses to viral and bacterial pathogens required the presence of CD11c(high) DCs. After peripheral Toll-like receptor (TLR) stimulation, NK cells were recruited to local lymph nodes, and their interaction with DCs resulted in the emergence of effector NK cells in the periphery. NK cell priming was dependent on the recognition of type I IFN signals by DCs; and the subsequent production and trans-presentation of IL-15 by DCs to resting NK cells. CD11c(high) DC-derived IL-15 was necessary and sufficient for the priming of NK cells. Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system.