Investigation of [18F]2-fluoro-2-deoxyglucose for the measure of myocardial glucose metabolism.
Investigation of [18F]2-fluoro-2-deoxyglucose for the measure of myocardial glucose metabolism.
复制标题
[18F]2-氟-2-脱氧葡萄糖用于测量心肌葡萄糖代谢的研究。
作者：
M. Phelps;E. Hoffman;C. Selin;S. C. Huang;G. Robinson;N. Macdonald;H. Schelbert;D. Kuhl
研究将氟 18 标记的 2-脱氧葡萄糖 (FDG) 作为葡萄糖类似物用于测量心肌葡萄糖代谢。研究了心肌摄取和保留、血液清除、物种依赖性（狗、猴、人）以及饮食对摄取的影响。狗和猴的正常心肌摄取 FDG 为注射剂量的 3% 至 4%，人为 1% 至 4%，而狗的脑摄取量为 1.5% 至 3%，猴为 5% 至 6%，人为 4% 至 8%。非空腹（糖酵解）状态下的心肌葡萄糖代谢率（MR）是空腹（生酮）状态下的2.8倍。人类受试者在正常进餐后表现出比主要含有游离脂肪酸（FFA）的进餐后更高的心肌摄取。血液清除速度很快，初始清除时间t/sub 1/2/为0.2至0.3分钟，随后狗的t/sub 1/2/为8.4±1.2分钟，人为11.6±1.1分钟。第三个小部分的半场时间在狗和人中分别为 59 ± 10 分钟和 88 ± 4 分钟。使用 ECAT 正电子断层扫描仪，发现心脏和血液（狗 3.5/1，人 14/1）、心脏和肺（狗 9/1，人 20/1）以及心脏和肝脏（狗 15/1，人 10/1）之间存在高图像对比度。 FDG 被心肌快速吸收，在 4 小时内没有任何明显的组织清除。 FDG表现出优异的成像特性。在具有高、中、低分辨率的 ECAT 断层扫描的人类受试者中获得注射的 12K、20K 和 40K c/min-mCi 的平均计数率。使用 EACT 测定体内葡萄糖和 FFA MR 提供了一种研究和评估人类缺血性心脏病中有氧和无氧代谢率变化的方法。 « less
Fluorine-18-labeled 2-deoxyglucose (FDG) was studied as a glucose analog for the measure of myocardial glucose metabolism. Myocardial uptake and retention, blood clearance, species dependence (dog, monkey, man), and effect of diet on uptake were investigated. Normal myocardial uptake of FDG was 3 to 4% of injected dose in dog and monkey, and 1 to 4% in man, compared with brain uptakes of 1.5 to 3% in dog, 5 to 6% in monkey, and 4 to 8% in man. The myocardial metabolic rate (MR) for glucose in the nonfasting (glycolytic) state was 2.8 times that in the fasting (ketogenic) state. Human subjects showed higher myocardial uptake after a normal meal than after a meal containing mostly free fatty acids (FFA). Blood clearance was rapid with initial clearance t/sub 1/2/ of 0.2 to 0.3 min, followed by a t/sub 1/2/ of 8.4 +- 1.2 min in dog and 11.6 +- 1.1 min in man. A small third component had half-times of 59 +- 10 min and 88 +- 4 min in dog and man, respectively. With the ECAT positron tomograph, high image-contrast ratios were found between heart and blood (dog 3.5/1, man 14/1), heart and lung (dog 9/1, man 20/1), and heartmore » and liver (dog 15/1, man 10/1). The FDG was taken up rapidly by the myocardium without any significant tissue clearance over a 4-hr period. The FDG exhibited excellent imaging properties. Average counting rates of 12K, 20K, and 40K c/min-mCi injected are obtained in human subjects with high, medium, and low resolutions of the ECAT tomograph. Determination of glucose and FFA MR in vivo with EACT provides a method for investigation and assessment of changing aerobic and anaerobic metabolic rates in ischemic heart disease in man.« less