Whole-body protein metabolism in lactating and nonlactating women.
Whole-body protein metabolism in lactating and nonlactating women.
复制标题
哺乳期和非哺乳期妇女的全身蛋白质代谢。
DOI：
10.1152/jappl.1989.66.1.370
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Garza,C
中科院分区：
文献类型：
--
作者：
Motil,KJ;Montandon,CM;Hachey,DL;Boutton,TW;Klein,PD;Garza,C
在产后1、5和12个月的妇女中，以及在通过氮平衡测量蛋白质和能量摄入量的控制饮食、恒定输注[13 C]碳酸氢盐和启动恒定输注[1- 13 C]亮氨酸和[α-15 N]-赖氨酸期间的未经产对照中，描述了身体蛋白质代谢对哺乳的适应性反应。哺乳期妇女的膳食能量摄入量比未经产对照组高27%。尽管存在这些差异，但哺乳期女性的氮平衡显著低于非哺乳期女性（-4.0 +/- 37.8 vs. +44.7 +/- 30.8 mg.kg-1.day-1）。在两组妇女的空腹条件下，检测到氨基酸通量、氧化或掺入蛋白质的差异无统计学意义。然而，哺乳期妇女的膳食摄入量和蛋白质代谢变量之间存在显著正相关。更全面地了解调节膳食营养素进入母体储存或产奶量的机制，将有助于确定哺乳期妇女的营养需求。
The adaptive responses of body protein metabolism to lactation were characterized in women at 1, 5, and 12 mo postpartum and in nulliparous controls during a controlled diet of measured protein and energy intakes by nitrogen balance, a constant infusion of [13C]bicarbonate, and a primed constant infusion of [1–13C]leucine and [alpha-15N]-lysine. Dietary energy intakes in the lactating women were 27% greater than those in the nulliparous controls. Despite these differences, lactating women had significantly lower nitrogen balances compared with the nonlactating women (-4.0 +/- 37.8 vs. +44.7 +/- 30.8 mg.kg-1.day-1). No significant differences in amino acid flux, oxidation, or incorporation into protein were detected during fasting conditions in the two groups of women. However, significantly positive associations were noted between dietary intakes and the variables of protein metabolism in the lactating women. A more complete understanding of the mechanisms that regulate the disposition of dietary nutrients into maternal body stores or milk production will enhance the determination of nutrient requirements in lactating women.