The angiotensin AT1 receptor antagonist, losartan, induces barrel rotation in the rat.
The angiotensin AT1 receptor antagonist, losartan, induces barrel rotation in the rat.
复制标题
血管紧张素 AT1 受体拮抗剂氯沙坦可诱导大鼠进行桶状旋转。
DOI：
10.1016/s0014-2999(98)00819-x
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发表时间：
1998
影响因子：
5
通讯作者：
K. Yamada
中科院分区：
文献类型：
--
作者：
A. Kawachi;M. Miyashita;T. Motoya;K. Yamada
侧脑室注射[Arg 8]加压素（500 ng/rat）或内皮素-1（70 ng/rat）至右侧脑室诱导大鼠沿身体长轴沿着旋转（桶旋转）。血管紧张素AT_（11）受体拮抗剂氯沙坦（10-200 μg/只）也能诱发大鼠桶形旋转，而加压素和内皮素受体拮抗剂不能抑制这种作用。然而，注射高剂量另一种血管紧张素II受体拮抗剂[Sar 1，Ile 8]血管紧张素II（100 μg/大鼠）或血管紧张素II（10 μg/大鼠）后，未观察到桶旋转。结果表明，氯沙坦确实引起桶旋转，这可能不是通过加压素和内皮素受体介导的。
Intracerebroventricular injections of [Arg8]vasopressin (500 ng/rat) or endothelin-1 (70 ng/rat) into the right lateral ventricle induced rotation along the long axis of the body (barrel rotation) in rats. Losartan (10–200 μg/rat), an angiotensin AT1receptor antagonist, also evoked barrel rotation, which was not inhibited by vasopressin and endothelin receptor antagonists. However, barrel rotation was not observed after injections of high doses of another angiotensin II receptor antagonist, [Sar1,Ile8]angiotensin II (100 μg/rat), or after angiotensin II (10 μg/rat). The results indicate that losartan does evoke barrel rotation which may be not mediated via vasopressin and endothelin receptors.