Beyond Neurons: Long Distance Communication in Development and Cancer.
Beyond Neurons: Long Distance Communication in Development and Cancer.
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DOI：
10.3389/fcell.2021.739024
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发表时间：
2021
影响因子：
5.5
通讯作者：
Payne SL
中科院分区：
文献类型：
--
作者：
McMillen P;Oudin MJ;Levin M;Payne SL
细胞通讯在组织和生物体功能的各个方面都很重要，从单细胞、两个离散群体和身体的远处组织的水平。长距离通信网络将单个细胞整合到组织中，以在发育过程中维持复杂的有机体，但当细胞之间的通信出现问题时，就会出现癌症等疾病状态。在此，我们讨论越来越多的证据表明，已知的神经元采用的通信方法也存在于其他细胞类型中。我们确定了长距离通信的三个主要领域：生物电信号、隧道纳米管 (TNT) 和巨噬细胞网络调节，并对这些系统在发育和癌症背景下的运作方式进行了比较。生物电信号通过离子和组织水平电场的交换在细胞之间发生，导致生化梯度和分子信号传导途径的变化，以控制癌症的正常发育和肿瘤生长和侵袭。 TNT 可以长距离运输关键的形态发生素和其他物质，介导电耦合、组织模式和癌细胞的恶性。最后，巨噬细胞在发育过程中通过囊泡运输维持长距离信号网络，提供通信中继并启动有利于癌症转移的微环境。通过比较发育和癌症背景下的非神经长距离信号传导，我们的目标是鼓励这两个领域之间的交叉交流，以培育新的假设和潜在的治疗策略。
Cellular communication is important in all aspects of tissue and organism functioning, from the level of single cells, two discreet populations, and distant tissues of the body. Long distance communication networks integrate individual cells into tissues to maintain a complex organism during development, but when communication between cells goes awry, disease states such as cancer emerge. Herein we discuss the growing body of evidence suggesting that communication methods known to be employed by neurons, also exist in other cell types. We identify three major areas of long-distance communication: bioelectric signaling, tunneling nanotubes (TNTs), and macrophage modulation of networks, and draw comparisons about how these systems operate in the context of development and cancer. Bioelectric signaling occurs between cells through exchange of ions and tissue-level electric fields, leading to changes in biochemical gradients and molecular signaling pathways to control normal development and tumor growth and invasion in cancer. TNTs transport key morphogens and other cargo long distances, mediating electrical coupling, tissue patterning, and malignancy of cancer cells. Lastly macrophages maintain long distance signaling networks through trafficking of vesicles during development, providing communication relays and priming favorable microenvironments for cancer metastasis. By drawing comparisons between non-neural long distance signaling in the context of development and cancer we aim to encourage crosstalk between the two fields to cultivate new hypotheses and potential therapeutic strategies.
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影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
3.3
作者：
Cervera, Javier;Meseguer, Salvador;Mafe, Salvador
通讯作者：
Mafe, Salvador
影响因子：
2.7
作者：
Danilchik, Michael;Williams, Melissa;Brown, Elizabeth
通讯作者：
Brown, Elizabeth
影响因子：
--
作者：
Chernet BT;Adams DS;Lobikin M;Levin M
通讯作者：
Levin M
影响因子：
5.6
作者：
Diaz, Daniel;Delgadillo, Dulce Maria;Gomora, Juan Carlos
通讯作者：
Gomora, Juan Carlos