Multicomponent therapeutics for networked systems
Multicomponent therapeutics for networked systems
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DOI：
10.1038/nrd1609
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发表时间：
2005-01-01
影响因子：
120.1
通讯作者：
Stockwell, BR
中科院分区：
文献类型：
--
作者：
Keith, CT;Borisy, AA;Stockwell, BR
包含多于一种活性成分的治疗方案通常用于临床医学。尽管如此，大多数药物发现努力寻找由单一化学实体组成的药物。早期药物发现过程中的重点是识别和优化分子组合的活性，可以识别出更有效的药物方案。系统观点有助于理解此类药物组合的作用机制。
Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.