Hepatic control elements promote long‐term expression of human coagulation factor IX gene in hydrodynamically transfected mice
Hepatic control elements promote long‐term expression of human coagulation factor IX gene in hydrodynamically transfected mice
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DOI：
10.1002/jgm.1583
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发表时间：
2011-07
期刊：
影响因子：
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通讯作者：
H. Kim;Jong Chul Kim;Yeon Kyung Lee;Jung Seok Kim;Y. Park
中科院分区：
文献类型：
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作者：
H. Kim;Jong Chul Kim;Yeon Kyung Lee;Jung Seok Kim;Y. Park
递送的靶基因的长期表达是基因治疗成功的关键。最近，来自载脂蛋白（apo）C‐I假基因的肝脏控制区I （HCR I）被证明是小鼠肝脏中长期基因表达的关键因素。HCR II是apoC‐I的另一个肝脏控制区域。
Long‐term expression of the delivered target gene is critical for successful gene therapy. Recently, hepatic control region I (HCR I) originating from the apolipoprotein (apo)C‐I pseudogene was shown to be a critical element for long‐term gene expression in the liver of mice. HCR II is another hepatic control region of apoC‐I.