Bile acid malabsorption as a cause of chronic diarrhea -: Diagnostic value of 7α-hydroxy-4-cholesten-3-one in serum
Bile acid malabsorption as a cause of chronic diarrhea -: Diagnostic value of 7α-hydroxy-4-cholesten-3-one in serum
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DOI：
10.1023/a:1026681512303
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发表时间：
1999-01-01
影响因子：
3.1
通讯作者：
Paumgartner, G
中科院分区：
文献类型：
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作者：
Sauter, GH;Munzing, W;Paumgartner, G
为评价血清7α-羟基-4-胆固酮(HCO)浓度作为胆汁酸吸收不良的诊断指标的价值，我们测定了106例正常人(年龄40.2±16.8岁；女性55例，男性51例)的HCO参考范围，并对23例原因不明的慢性腹泻患者(年龄49.4±15.3岁，女性13例，男性10例)进行了实用研究。胆汁酸吸收不良的诊断是基于口服后[Se-75]高胆基牛磺酸的滞留减少(75SeHCAT试验)。HCO(参考范围：6-48 ng/ml)和(75)SeHCAT试验在19/23(83%)患者中得到相同的结果。胆汁酸吸收不良以血清中HCO升高为标准，其敏感性为90%，特异性为79%。血清HCO检测可作为诊断不明原因慢性腹泻患者胆汁酸吸收不良的一种新的、简便、敏感的方法。
To evaluate the usefulness of 7 alpha-hydroxy-4-cholesten-3-one (HCO) serum concentrations as a diagnostic marker of bile acid malabsorption, we determined the reference range of HCO in 106 normal subjects (age 40.2 +/- 16.8 years; 55 women, 51 men) and conducted a utility study in 23 patients with chronic diarrhea of unknown origin (age 49.4 +/- 15.3 years, 13 women, 10 men). The diagnosis of bile acid malabsorption was made on the basis of a decreased retention of [Se-75]homocholyltaurine after oral application ((75)SeHCAT test). HCO (reference range: 6-48 ng/ml) and the (75)SeHCAT test yielded the same results in 19/23 (83%) patients. Bile acid malabsorption was identified by an increase of HCO in serum with a sensitivity of 90% and a specificity of 79%. Analysis of HCO in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.