Cell Cycle: Abrogating Interphase/M Phase Bistability.

Cell Cycle: Abrogating Interphase/M Phase Bistability.
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细胞周期:消除间期/M 期双稳定性。

DOI:
10.1016/j.cub.2018.10.011
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发表时间:
2018
期刊:
Current biology : CB
影响因子:
--
通讯作者:
Goldberg,MichaelL
Goldberg,MichaelL
中科院分区:
--
文献类型:
--
作者:
Goldberg,MichaelL

文献摘要

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一项新的研究报告了通过同时破坏控制主要有丝分裂驱动因子Cdk1-cyclin B及其抵消磷酸酶PP2A-B55活性的反馈回路,能够产生陷入间期和M期之间“无人区”的细胞的能力。
A new study reports the ability to generate cells caught in a ‘no-man's land' between interphase and M phase by simultaneously disrupting feedback loops controlling the activities of the main mitotic driver Cdk1–cyclin B and its counteracting phosphatase PP2A-B55.