ACUTE NONLYMPHOCYTIC LEUKEMIA IN 171 CHILDREN
ACUTE NONLYMPHOCYTIC LEUKEMIA IN 171 CHILDREN
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DOI：
10.1002/mpo.2950020203
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发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
SIMONE J V
中科院分区：
文献类型：
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作者：
CHOI S-I;SIMONE J V
描述了171例急性非淋巴细胞白血病（ANLL）儿童的初始特征、治疗反应、并发症、死亡原因和预后因素，并与成人ANLL和儿童ALL的历史数据进行了比较。ANLL儿童和成人之间的主要差异包括CNS白血病的频率较高，儿童早期死亡的频率较低。ANLL和ALL [急性淋巴细胞白血病]儿童之间最重要的区别是没有ANLL发病的高峰年龄和ALL对治疗的反应更好。血小板计数在100，000/mm 3或以上且无明显肝肿大的患者生存期显著延长，而血小板计数低于10，000/mm 3的患者生存期显著缩短。自1968年以来使用的3种方案的缓解频率和持续时间比以前更好。即使采用这些方案，结果也远不令人满意，完全缓解率为66%，血液学缓解的中位持续时间为6个月。中位生存期为10个月。儿童ANLL的这些结果与儿童ALL的当前结果的鲜明对比强调了对ANLL的新颖的、富有想象力的治疗方法的需要。
The initial features, response to therapy, complications, cause of death and prognostic factors of 171 children with ANLL [acute nonlymphocytic leukemia] are described and compared to historical data for adults with ANLL and children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL [acute lymphocytic leukemia] are the absence of a peak age of incidence in ANLL and the better response to therapy in ALL. At platelet counts of 100,000/mm3 or above and no palpable hepatomegaly significantly longer survival was noted, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were better with 3 protocols used since 1968 than previously. Even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 mo. and a median duration of survival of 10 mo. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.