Interactions between the sexual identity of the nervous system and the social environment mediate lifespan in Drosophila melanogaster.
Interactions between the sexual identity of the nervous system and the social environment mediate lifespan in Drosophila melanogaster.
复制标题
DOI：
10.1098/rspb.2018.1450
复制
发表时间：
2018-11-28
期刊：
影响因子：
--
通讯作者：
Wigby S
中科院分区：
文献类型：
--
作者：
Flintham EO;Yoshida T;Smith S;Pavlou HJ;Goodwin SF;Carazo P;Wigby S
寿命上的性别差异是普遍存在的，但其潜在的原因仍然知之甚少。众所周知，雌雄之间和雌雄之间的社会互动会影响许多分类群的寿命，但事实证明，将性别特异性行为的作用与两性之间更广泛的生理差异区分开来是一项挑战。为了解决这个问题，我们从基因上控制了黑腹果蝇神经系统的性别特征，从而控制了它们的性行为，并测量了它们在不同社会条件下的寿命。与以往的研究一致，雌性神经系统的男性化导致雄性特有的求偶行为和攻击，而雄性神经系统的女性化则导致雄性之间的求偶行为和攻击减少。对照组的雌性比雄性寿命长，但男性化的雌性群体表现出与男性相似的寿命和群体生活成本。通过改变社会群体中控制和男性化女性的混合，我们表明，男性特有的行为对接受者来说是昂贵的，即使是从女性那里接受的。然而，与最近的研究结果一致，我们的数据表明，求爱表达的成本低得惊人。总的来说，我们的研究表明，神经系统介导的性别特异性行为的表达本身独立于两性之间更广泛的生理差异，或接受攻击或求爱，在调节寿命的性别差异中发挥有限的作用。
Sex differences in lifespan are ubiquitous, but the underlying causal factors remain poorly understood. Inter- and intrasexual social interactions are well known to influence lifespan in many taxa, but it has proved challenging to separate the role of sex-specific behaviours from wider physiological differences between the sexes. To address this problem, we genetically manipulated the sexual identity of the nervous system—and hence sexual behaviour—in Drosophila melanogaster, and measured lifespan under varying social conditions. Consistent with previous studies, masculinization of the nervous system in females induced male-specific courtship behaviour and aggression, while nervous system feminization in males induced male–male courtship and reduced aggression. Control females outlived males, but masculinized female groups displayed male-like lifespans and male-like costs of group living. By varying the mixture of control and masculinized females within social groups, we show that male-specific behaviours are costly to recipients, even when received from females. However, consistent with recent findings, our data suggest courtship expression to be surprisingly low cost. Overall, our study indicates that nervous system-mediated expression of sex-specific behaviour per se—independent of wider physiological differences between the sexes, or the receipt of aggression or courtship—plays a limited role in mediating sex differences in lifespan.
登录
查看更多内容
影响因子：
2.1
作者：
Crudgington, H. S.;Fellows, S.;Snook, R. R.
通讯作者：
Snook, R. R.
DOI：
10.1098/rspb.2007.1138
发表时间：
2007-12-22
影响因子：
4.7
作者：
Clutton-Brock, T. H.;Isvaran, K.
通讯作者：
Isvaran, K.
DOI：
10.1126/science.1243339
发表时间：
2014-01-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gendron CM;Kuo TH;Harvanek ZM;Chung BY;Yew JY;Dierick HA;Pletcher SD
通讯作者：
Pletcher SD
影响因子：
2.5
作者：
Gaskin, T;Futerman, P;Chapman, T
通讯作者：
Chapman, T
影响因子：
64.8
作者：
Carazo P;Tan CK;Allen F;Wigby S;Pizzari T
通讯作者：
Pizzari T