The impact of induction chemotherapy on long-term quality of life in patients with locoregionally advanced nasopharyngeal carcinoma: Outcomes from a randomised phase 3 trial
The impact of induction chemotherapy on long-term quality of life in patients with locoregionally advanced nasopharyngeal carcinoma: Outcomes from a randomised phase 3 trial
复制标题
诱导化疗对局部晚期鼻咽癌患者长期生活质量的影响：随机 3 期试验的结果
DOI：
10.1016/j.oraloncology.2021.105494
复制
发表时间：
2021
期刊：
影响因子：
4.8
通讯作者：
Chen Ming-Yuan
中科院分区：
文献类型：
--
作者：
Yang Qi;Xia Le;Lin Mei;Zhang Meng-Xia;Duan Chong-Yang;Liu You-Ping;Xie Yu-Long;Wang Zhi-Qiang;You Rui;Zou Xiong;Hua Yi-Jun;Huang Pei-Yu;Sun Rui;Hong Ming-Huang;Chen Ming-Yuan
背景我们先前的试验证实诱导化疗（IC）可改善局部晚期鼻咽癌（NPC）患者的长期生存结局。在这项研究中，我们调查了IC对长期生活质量（QoL）的影响，在本cohol.MethodsOur试验是一个随机的，开放标签的3期临床试验比较IC其次是同步放化疗（CCRT）与CCRT单独在III-IVB期（除T3 N 0 -1）鼻咽癌患者。所有参与者都完成了两份自填式问卷，即欧洲癌症研究和治疗组织（EORTC）生活质量问卷C30（QLQ-C30）和EORTC QLQ头颈部癌症特异性模块（H&N35）。根据方案，必须在患者了解治疗分配之前完成问卷（基线）。然后接近患者在本研究period. ResultsUltimate的时间，从228例患者的生活质量数据被纳入分析。从基线到最后一次随访，两组的大多数量表在统计学和临床上均降低。最后一次随访时，IC组在QLQ-C30量表中的角色功能、认知功能、社会功能、疲劳、疼痛和便秘方面的结局明显更好。同样，在H&N35量表中，观察到疼痛，性行为，粘性唾液，止痛药的使用，营养补充剂和减肥，但在感官问题较差的结果，为那些治疗IC其次是CCRT.ConclusionIC其次是CCRT似乎有更好的长期生活质量的结果相比，CCRT单独在局部晚期鼻咽癌患者。
BackgroundOur previous trial confirmed that induction chemotherapy (IC) improved long-term survival outcomes in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). In this study, we investigated the impact of IC on long-term quality of life (QoL) in this cohort.MethodsOur trial was a randomised, open-label phase 3 trial comparing IC followed by concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients with stage III-IVB (except T3N0-1) NPC. All participants completed two self-administered questionnaires, the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire C30 (QLQ-C30) and the EORTC QLQ Head and Neck Cancer–Specific Module (H&N35). As per protocol, the questionnaires had to be completed before knowledge of treatment allocation by the patient (baseline). Patients were then approached to enroll at the time of the present study period.ResultsUltimately, QoL data from 228 patients were included in the analysis. Most scales were both statistically and clinically decreased in both groups between baseline and the latest follow-up. The IC followed by CCRT group had significantly better outcome in role functioning, cognitive functioning, social functioning, fatigue, pain, and constipation in QLQ-C30 scales at the last follow-up. Similarly, in H&N35 scales, a significantly better result was observed in pain, sexuality, sticky saliva, pain killers use, nutritional supplements, and weight loss, but a poorer result in senses problems, for those treated by IC followed by CCRT.ConclusionIC followed by CCRT seemed to have better long-term QoL outcomes compared with CCRT alone in patients with locoregionally advanced NPC.