Nano-Hydroxyapatite and Calcium-Enriched Mixture for Pulp Capping of Sound Primary Teeth: A Randomized Clinical Trial
Nano-Hydroxyapatite and Calcium-Enriched Mixture for Pulp Capping of Sound Primary Teeth: A Randomized Clinical Trial
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DOI：
10.22037/iej.v10i2.7910
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发表时间：
2015-03
影响因子：
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通讯作者：
R. Haghgoo;S. Asgary;Fatemeh Mashhadi Abbas;Roshanak Montazeri Hedeshi
中科院分区：
文献类型：
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作者：
R. Haghgoo;S. Asgary;Fatemeh Mashhadi Abbas;Roshanak Montazeri Hedeshi
简介：纳米羟基磷灰石（NHA）已用于骨缺损的再生。富钙混合物（CEM）水泥也用于各种牙科治疗。本试验比较了NHA和CEM水门汀用于健康乳牙直接盖髓（DPC）的疗效。方法和材料：本研究采用裂口设计，随机选取健康乳牙20只，在获得知情同意后，进行拔牙实验。在机械牙髓暴露后，暴露部位用NHA或CEM粘固剂覆盖，然后立即用玻璃离子和树脂复合物修复。两个月后拔牙并进行组织学检查。比较两组硬组织桥形成的参数、类型、质量及牙髓炎症评分。使用Mann Whitney U和Fisher精确检验分析数据。显著性水平设定为0.001。结果：所有CEM标本的炎症评分均为0（小于10%）。NHA组中，2例（20%）、4例（40%）和4例（40%）标本的炎症评分分别为0分（<10%）、1分（10%~ 30%）和2分（30%~ 50%）（P<0.001）。所有CEM标本均有HTB形成，而NHA标本中有2例HTB形成（20%; P<0.001）。所有CEM标本均显示正常牙髓，NHA组仅2例（20%）显示正常牙髓未发炎。结论：在HTB形成和牙髓炎症评分方面，CEM骨水泥作为DPC试剂优于NHA，但其上级。它是一种适合于乳牙DPC的材料。
Introduction: Nano-hydroxyapatite (NHA) has been used for regeneration of osseous defects. Calcium-enriched mixture (CEM) cement is also used for various dental treatments. This trial compared the efficacy of NHA and CEM cement for direct pulp capping (DPC) of sound primary teeth. Methods and Materials: In this randomized clinical trial with split-mouth design, after attaining informed consent, 20 sound primary canines scheduled for orthodontic extraction, were selected. After mechanical pulp exposure, the exposed site was capped with either NHA or CEM cement and then immediately restored with glass-ionomer and resin composite. The teeth were extracted after two months and examined histologically. Parameters of hard tissue bridge (HTB) formation, its type and quality as well as pulpal inflammation scores were compared between the two experimental groups. The data were analyzed using the Mann Whitney U and Fisher’s exact test. The level of significance was set at 0.001. Results: All CEM specimens showed inflammation score of 0 (less than 10%). However, in NHA group, inflammation scores of 0 (less than 10%), 1 (10%-30%) and 2 (30%-50%) were observed in 2 (20%), 4 (40%) and 4 (40%) specimens, respectively (P<0.001). HTB was formed in all CEM specimens while it was developed in 2 specimens of NHA (20%; P<0.001). All CEM specimens showed normal pulp; only two cases in NHA group (20%) demonstrated uninflamed normal pulp. Conclusion: CEM cement was superior to NHA as a DPC agent in terms of HTB formation and pulp inflammation scores. It is a suitable material for the DPC of primary teeth.