Trends in the indications for penetrating keratoplasty in Shandong, 2005-2010
Trends in the indications for penetrating keratoplasty in Shandong, 2005-2010
复制标题
DOI：
10.3980/j.issn.2222-3959.2011.05.07
复制
发表时间：
2011-10-18
影响因子：
1.4
通讯作者：
Zhao, Jing
中科院分区：
文献类型：
--
作者：
Wang, Jun-Yi;Xie, Li-Xin;Zhao, Jing
目的：了解山东省穿透性角膜移植术(PKP)的适应证现状及趋势变化。方法：对2005年6月1日至2010年5月31日在山东省眼科研究所接受PKP的所有患者的病历进行回顾性分析。结果：5年期间共有875例(875只眼)接受PKP，占总数的61.6%。角膜 移植手术。 PKP的主要适应症是感染性角膜炎（37.1%）、HSK（19.1%）、圆锥角膜（11.2%）、大疱性角膜病（8.5%）、再移植（6.7%）和角膜疤痕（4.8%）。圆锥角膜的PKP比例逐年下降，而大疱性角膜病的比例逐年略有上升。真菌感染占感染性角膜炎病例的65.2%，仍然是角膜感染的主要原因。此外，54.1%的大疱性角膜病变病例与白内障手术有关。与再移植相关的主要初步诊断是感染性角膜炎（38.9%）、HSK（18.6%）和角膜烧伤（16.9%）。再移植的主要原因包括移植物内皮功能障碍（39.0%）、移植物溃疡（28.8%）和原发病复发（15.3%）。结论：感染性角膜炎仍然是山东地区PKP的主要适应症，真菌感染仍然是角膜感染的主要原因。大疱性角膜病的 PKP 病例百分比呈上升趋势，但圆锥角膜的百分比呈下降趋势。尽管在所有角膜移植手术中的总体比例有所下降，但PKP仍然是山东地区角膜移植的主要选择。
AIM: To identify the current indications and the trend shifts for penetrating keraboplasty (PKP) in Shandong.METHODS: The medical charts of all patients who underwent PKP at Shandong Eye Institute from June 1, 2005 to May 31, 2010 were analysed retrospectively.RESULTS: A total of 875 patients (875 eyes) received PKP in this 5-year period, accounting for 61.6% of all corneal transplantation surgeries. The leading indications for PKP were infectious keratitis (37.1%), HSK (19.1%), keratoconus (11.2%), bullous keratopathy (8.5%), regrafting (6.7%) and corneal scarring (4.8%). The percentage of PKP for keratoconus declined year by year, whereas the percentage of bullous keratopathy had a mild annual increase. Fungal infections accounted for 65.2% of the infectious keratitis cases, remaining the leading cause of corneal infection. In addition, 54.1% of bullous keratopathy cases were associated with cataract surgery. The leading initial diagnoses associated with regrafting were infectious keratitis (38.9%), HSK (18.6%) and corneal burn (16.9%). The major causes of regrafting included graft endothelial dysfunction (39.0%), graft ulcer (28.8%) and primary disease recurrence (15.3%).CONCLUSION: Infectious keratitis remained the leading indication for PKP in Shandong, and fungal infections were still the major cause of corneal infections. There was an increasing trend in the percentage of PKP cases indicated for bullous keratopathy but a decline in the same for keratoconus. Even with a decline in the overall proportion among all corneal transplantation surgeries, PKP is still the major corneal transplant choice in Shandong.