Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition
Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition
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DOI：
10.1111/j.1365-2249.2010.04286.x
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发表时间：
2011-02-01
影响因子：
4.6
通讯作者：
Tlaskalova-Hogenova, H.
中科院分区：
文献类型：
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作者：
Kverka, M.;Zakostelska, Z.;Tlaskalova-Hogenova, H.
共生细菌已被证明可以调节宿主的粘膜免疫系统。在这里，我们报告说，口服治疗的BALB/c小鼠的成分，副拟杆菌distasonis，显着降低肠道炎症的严重程度，在小鼠模型的急性和慢性结肠炎诱导的葡聚糖硫酸钠（DSS）。膜部分的P. distasonis（mPd）防止DSS诱导的几种促炎细胞因子的增加，增加mPd特异性血清抗体，并稳定肠道微生物生态。在严重联合免疫缺陷小鼠中未观察到口服mPd的抗结肠炎作用，可能涉及诱导特异性抗体应答和稳定肠道微生物群。我们的研究结果表明，特定的细菌成分来源于大肠杆菌，P. distasonis，可能是有用的慢性炎症性疾病，如炎症性肠病的新的治疗策略的发展。
Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology. The anti-colitic effect of oral mPd was not observed in severe combined immunodeficient mice and probably involved induction of specific antibody responses and stabilization of the intestinal microbiota. Our results suggest that specific bacterial components derived from the commensal bacterium, P. distasonis, may be useful in the development of new therapeutic strategies for chronic inflammatory disorders such as inflammatory bowel disease.