Three-dimensional electromagnetic model of the human eye: advances towards the optimisation of electroretinographic signal detection
Three-dimensional electromagnetic model of the human eye: advances towards the optimisation of electroretinographic signal detection
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DOI：
10.1007/bf02513372
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发表时间：
1999-11-01
影响因子：
3.2
通讯作者：
Parks, S
中科院分区：
文献类型：
--
作者：
Job, HM;Keating, D;Parks, S
经典的电磁理论被用来研究由特定的视网膜刺激引起的角膜表面电位的地形变化。从三维数学模型的结果表明，超过97%的计算电磁场电位位于3%的以前的分析模型数据的轴对称的情况下。产生角膜电位图，其显示为特定视网膜刺激和位置的特征。发现对于全视野全局刺激，角膜电位的最大变化约为1%。这被认为是令人鼓舞的，因为当前的电生理学技术从单个角膜或巩膜部位测量眼电位，其位置通常难以定位和再现。该模型用于模拟中枢和外周刺激和暗点条件。20度中心暗点模拟显示中央角膜电位的总体降低仅为3%，而发现外围刺激引起该电位的高达10%的变化。因此，存在用于多焦点视网膜刺激的单个记录位点不理想的可能性。这些数据可用于建议更合适的电极记录位置，以实现最大信号恢复，尤其是优化多焦视网膜电图刺激的信号检测。
Classical electromagnetic theory is used to examine the topographical variation in electrical potentials over the corneal surface resulting from specific retinal stimuli. Results from a three-dimensional mathematical model show that over 97% of calculated electromagnetic field potentials lie within 3% of previous analytical model data for an axially symmetric case. Maps of corneal potentials are produced that are shown to be characteristic of specific retinal stimuli and location. The maximum variation in corneal potential for a full field global stimulus is found to be approximately 1%. This is considered encouraging, as current electrophysiology techniques measure ocular potentials from a single corneal or scleral site, the position of which is often difficult to localise and reproduce. The model is used to simulate both central and peripheral stimuli and scotoma conditions. A 20 degrees central scotoma simulation shows an overall reduction in central corneal potential of only 3%, whereas peripheral stimuli are found to cause up to 10% variations in this potential. There is therefore a possibility that a single recording site for multifocal retinal stimulation is not ideal. These data may be used to suggest more appropriate electrode recording positions for maximum signal recovery, not least in optimising signal detection for multi-focal electroretinography stimulation.