Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in ParkinsonCs disease
Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in ParkinsonCs disease
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DOI：
10.1007/s11011-009-9139-4
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发表时间：
2009-06-01
影响因子：
3.6
通讯作者：
Wajner, Moacir
中科院分区：
文献类型：
--
作者：
dos Santos, Eliseu Felippe;Brandt Busanello, Estela Natacha;Wajner, Moacir
在本研究中，我们测量了帕金森病（PD）患者和年龄匹配的对照组的血液总同型半胱氨酸（（t）Hcy）、维生素B-12和叶酸水平，并寻找这些水平与PD患者吸烟、饮酒、左旋多巴治疗和疾病持续时间之间的可能联系。我们最初观察到，与对照组相比，受PD影响的患者的血浆（t）Hcy水平升高约30%。线性相关、多元回归和比较分析显示，PD患者血浆（t）Hcy水平升高的主要决定因素是叶酸缺乏，而对照组血浆（t）Hcy水平主要由维生素B-12浓度决定。我们还观察到，酒精消费，性别和左旋多巴治疗并没有显着改变血浆（t）同型半胱氨酸，叶酸和维生素B-12水平在帕金森病患者。此外，病程与（t）Hcy水平呈正相关，吸烟与PD患者叶酸缺乏有关。考虑到同型半胱氨酸增加和叶酸缺乏对中枢神经系统的潜在协同有害作用，我们假设，叶酸应补充到受PD影响的患者，以使血液同型半胱氨酸和叶酸水平正常化，从而潜在地避免这种疾病的神经功能恶化的这些危险因素。
In the present work we measured blood levels of total homocysteine ((t)Hcy), vitamin B-12 and folic acid in patients with ParkinsonCs disease (PD) and in age-matched controls and searched for possible associations between these levels with smoking, alcohol consumption, L-DOPA treatment and disease duration in PD patients. We initially observed that plasma (t)Hcy levels were increased by around 30 % in patients affected by PD compared to controls. Linear correlation, multiple regression and comparative analyses revealed that the major determinant of the increased plasma concentrations of (t)Hcy in PD patients was folic acid deficiency, whereas in controls (t)Hcy levels were mainly determined by plasma vitamin B-12 concentrations. We also observed that alcohol consumption, gender and L-DOPA treatment did not significantly alter plasma (t)Hcy, folic acid and vitamin B-12 levels in parkinsonians. Furthermore, disease duration was positively associated with (t)Hcy levels and smoking was linked with a deficit of folic acid in PD patients. Considering the potential synergistic deleterious effects of Hcy increase and folate deficiency on the central nervous system, we postulate that folic acid should be supplemented to patients affected by PD in order to normalize blood Hcy and folate levels, therefore potentially avoiding these risk factors for neurologic deterioration in this disorder.