THYROTROPIN-RELEASING HORMONE-LIKE MATERIAL IN HUMAN RETINA
THYROTROPIN-RELEASING HORMONE-LIKE MATERIAL IN HUMAN RETINA
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DOI：
10.1007/bf03348274
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发表时间：
1980-01-01
影响因子：
5.4
通讯作者：
BASCHIERI, L
中科院分区：
文献类型：
--
作者：
MARTINO, E;NARDI, M;BASCHIERI, L
在尸检用于角膜移植的眼睛时获得的人类视网膜中发现了促甲状腺激素释放激素[甲状腺激素]（TRH）样物质。TRH样物质用甲醇提取，在其免疫反应性和生物反应性以及新鲜人血清的蛋白水解降解中与合成TRH没有区别。人视网膜中TRH浓度与人大脑皮质中的浓度相似。这些数据与视网膜是中枢神经系统延伸的观点一致。人类视网膜TRH的生理功能尚不清楚，它可能作为一种神经递质。
Thyrotropin-releasing hormone [thyroliberin] (TRH)-like material was found in human retina obtained at autopsy from eyes used for corneal grafts. The TRH-like material was extracted with methanol and was indistinguishable from synthetic TRH in its immunoreactivity and bioreactivity and in its proteolytic degradation by fresh human serum. The TRH concentration in human retina was similar to that reported in human cerebral cortex. These data are in keeping with the notion that the retina is an extension of the CNS. The physiological function of human retinal TRH is unknown; it probably acts as a neurotransmitter.