Androgen Action in Prostate Cancer
Androgen Action in Prostate Cancer
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DOI：
10.1007/s12672-010-0044-4
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发表时间：
2010-10-01
影响因子：
3
通讯作者：
Tindall, Donald J.
中科院分区：
文献类型：
--
作者：
Basu, Sujit;Tindall, Donald J.
前列腺癌是世界范围内男性的主要健康问题。雄激素是前列腺生长和维持所必需的。雄激素通过与雄激素受体（AR）结合而起作用，雄激素受体是存在于前列腺组织中的核受体转录因子。大多数前列腺肿瘤也保留了雄激素依赖性;因此，雄激素消融通常是治疗晚期前列腺癌患者的首选初始治疗方法。这篇综述总结了目前关于雄激素在前列腺癌中的作用的信息。
Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor present in the prostate tissues. Most prostate tumors also retain their androgen dependence; therefore, androgen ablation is usually the preferred initial therapeutic approach for the treatment of advanced prostate cancer patients. This review summarizes the current information regarding the role of androgens in prostate cancer.