Genetic-environmental interaction in the genesis of aggressivity and conduct disorders.
Genetic-environmental interaction in the genesis of aggressivity and conduct disorders.
复制标题
DOI：
10.1001/archpsyc.1995.03950230030006
复制
发表时间：
1995-11
影响因子：
--
通讯作者：
R. Cadoret;W. Yates;E. Troughton;G. Woodworth;M. Stewart
中科院分区：
文献类型：
--
作者：
R. Cadoret;W. Yates;E. Troughton;G. Woodworth;M. Stewart
本研究的目的是确定不利的收养家庭环境对被收养者行为障碍、成人反社会行为和两种攻击性指标的影响，所有这些行为都有助于成人反社会人格障碍，也与药物滥用和/或依赖的脆弱性增加有关。方法：本研究采用了一种收养范式，在该范式中，被收养的后代在出生时与有记录（通过监狱和医院记录）的反社会人格障碍和/或酒精滥用或依赖的亲生父母分离，并在成年后进行随访。他们和他们的养父母都接受了面谈。这些被收养者与对照组进行了比较，对照组的生物学背景没有记录在案的精神病理学行为。研究对象为95名男性和102名女性被收养者及其养父母。结果采用多元回归分析分别对遗传和环境效应进行了分析。结果表明：（1）反社会人格障碍的生物学背景可预测青少年攻击性、行为障碍和成人反社会行为的增加;（2）不良的收养家庭环境（定义为养父母有婚姻问题、离婚、分居、焦虑、抑郁、药物滥用和/或依赖、法律的问题）可独立预测成人反社会行为的增加。不良的收养家庭环境与反社会人格障碍的生物背景相互作用，导致被收养者的攻击性和行为障碍显着增加，但在没有反社会人格障碍的生物背景的情况下。结论：环境效应和遗传环境相互作用解释了被收养者攻击性、行为障碍和成人反社会行为的显著差异，对行为障碍和相关疾病（如药物滥用和攻击性）的预防和干预具有重要意义。
BACKGROUND The purpose of this study was to determine the effect of an adverse adoptive home environment on adoptee conduct disorder, adult antisocial behavior, and two measures of aggressivity, all of which are behaviors that contribute to adult antisocial personality disorder and that also are associated with increased vulnerability to drug abuse and/or dependence. METHODS The study used an adoption paradigm in which adopted offspring who were separated at birth from biologic parents with documented (by prison and hospital records) antisocial personality disorder and/or alcohol abuse or dependence were followed up as adults. They and their adoptive parents were interviewed in person. These adoptees were compared with controls whose biologic background was negative for documented psychopathologic behavior. Subjects were 95 male and 102 female adoptees and their adoptive parents. RESULTS Multiple regression analysis was used to measure separately genetic and environmental effects. It showed that (1) a biologic background of antisocial personality disorder predicted increased adolescent aggressivity, conduct disorder, and adult antisocial behaviors, and (2) adverse adoptive home environment (defined as adoptive parents who had marital problems, were divorced, were separated, or had anxiety conditions, depression, substance abuse and/or dependence, or legal problems) independently predicted increased adult antisocial behaviors. Adverse adoptive home environment interacted with biologic background of antisocial personality disorder to result in significantly increased aggressivity and conduct disorder in adoptees in the presence of but not in the absence of a biologic background of antisocial personality disorder. CONCLUSIONS Environmental effects and genetic-environmental interaction account for significant variability in adoptee aggressivity, conduct disorder, and adult antisocial behavior and have important implications for the prevention and intervention of conduct disorder and associated conditions such as substance abuse and aggressivity.