Perspective - Applications of metabolomics in agriculture
Perspective - Applications of metabolomics in agriculture
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DOI：
10.1021/jf061218t
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发表时间：
2006-11-29
影响因子：
6.1
通讯作者：
Seiber, James N.
中科院分区：
文献类型：
--
作者：
Dixon, Richard A.;Gang, David R.;Seiber, James N.
生物系统极其复杂。植物和人类基因组的解开揭示了比预期的基因数量少。因此，其他过程，如基因表达的调节，基因产物的作用，以及催化蛋白质产生的代谢网络，必须对生命系统固有的显著多样性做出根本性贡献。代谢组学是一种相对较新的方法，旨在提高对这些代谢网络以及植物和其他生物有机体的后续生化组成的理解。代谢组学中的分析工具，包括质谱（MS）和核磁共振（NMR）光谱，可以分析时间，压力，营养状况和环境扰动对数百种代谢物的影响，同时产生大量复杂的数据集。这些信息与转录组学和蛋白质组学相结合，有可能产生更完整的食品和饲料产品组成的图片，优化作物性状的发展，并提高饮食和健康。从2005年3月举行的美国化学学会研讨会上选择的演讲已经组装，以突出在农业中的代谢组学的新兴应用。
Biological systems are exceedingly complex. The unraveling of the genome in plants and humans revealed fewer than the anticipated number of genes. Therefore, other processes such as the regulation of gene expression, the action of gene products, and the metabolic networks resulting from catalytic proteins must make fundamental contributions to the remarkable diversity inherent in living systems. Metabolomics is a relatively new approach aimed at improved understanding of these metabolic networks and the subsequent biochemical composition of plants and other biological organisms. Analytical tools within metabolomics including mass spectrometry ( MS) and nuclear magnetic resonance (NMR) spectroscopy can profile the impact of time, stress, nutritional status, and environmental perturbation on hundreds of metabolites simultaneously resulting in massive, complex data sets. This information, in combination with transcriptomics and proteomics, has the potential to generate a more complete picture of the composition of food and feed products, to optimize crop trait development, and to enhance diet and health. Selected presentations from an American Chemical Society symposium held in March 2005 have been assembled to highlight the emerging application of metabolomics in agriculture.