An Interactive Database for the Assessment of Histone Antibody Specificity.

An Interactive Database for the Assessment of Histone Antibody Specificity.
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DOI:
10.1016/j.molcel.2015.06.022
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发表时间:
2015-08-06
期刊:
影响因子:
16
通讯作者:
Strahl BD
Strahl BD
中科院分区:
生物学1区
文献类型:
--
作者:
Rothbart SB;Dickson BM;Raab JR;Grzybowski AT;Krajewski K;Guo AH;Shanle EK;Josefowicz SZ;Fuchs SM;Allis CD;Magnuson TR;Ruthenburg AJ;Strahl BD

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获得高质量的抗体是研究组蛋白及其翻译后修饰(PTM)的必要条件。在这里,我们推出了组蛋白抗体特异性数据库(www.histoneantibodies.com),这是一个在线且不断扩展的资源,通过肽微阵列对广泛使用的市售组蛋白抗体的行为进行编目。这个交互式门户网站为生物研究界提供了一个重要的资源,他们经常使用这些抗体作为检测试剂,用于广泛的应用。
Access to high quality antibodies is a necessity for the study of histones and their posttranslational modifications (PTMs). Here we debut The Histone Antibody Specificity Database (http://www.histoneantibodies.com), an online and expanding resource cataloguing the behavior of widely used commercially available histone antibodies by peptide microarray. This interactive web portal provides a critical resource to the biological research community who routinely use these antibodies as detection reagents for a wide range of applications.