Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats
Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats
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DOI：
10.1016/j.lmot.2006.07.004
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发表时间：
2007-02-01
影响因子：
1.4
通讯作者：
Bardo, Michael T.
中科院分区：
文献类型：
--
作者：
Klein, Emily D.;Gehrke, Brenda J.;Bardo, Michael T.
The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding. (c) 2006 Elsevier Inc. All rights reserved.
