Refining the nuclear auxin response pathway through structural biology.
Refining the nuclear auxin response pathway through structural biology.
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DOI：
10.1016/j.pbi.2015.05.007
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发表时间：
2015-10
影响因子：
9.5
通讯作者：
Strader LC
中科院分区：
文献类型：
--
作者：
Korasick DA;Jez JM;Strader LC
生长素是植物生长发育的关键调控因子。在过去的20年里，经典的分子和遗传技术确定了生长素介导的基因表达的主要参与者，并提出了一个典型的生长素反应途径。近年来，结构和生物物理研究阐明了生长素感知的分子细节，生长素转录因子对DNA的识别，以及生长素转录因子与抑制蛋白的相互作用。这些研究完善了生长素信号转导模型，提出了新的问题，增加了生长素信号转导的复杂性。
Auxin is a key regulator of plant growth and development. Classical molecular and genetic techniques employed over the past 20 years identified the major players in auxin-mediated gene expression and suggest a canonical auxin response pathway. In recent years, structural and biophysical studies clarified the molecular details of auxin perception, the recognition of DNA by auxin transcription factors, and the interaction of auxin transcription factors with repressor proteins. These studies refine the auxin signal transduction model and raise new questions that increase the complexity of auxin signaling.