Lung, chest wall, and total respiratory system resistances and elastances in the normal range of breathing.
Lung, chest wall, and total respiratory system resistances and elastances in the normal range of breathing.
复制标题
正常呼吸范围内的肺、胸壁和整个呼吸系统的阻力和弹性。
DOI：
10.1164/ajrccm/145.1.110
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Mendham,GE
中科院分区：
文献类型：
--
作者：
Barnas,GM;Campbell,DN;Mackenzie,CF;Mendham,JE;Fahy,BG;Runcie,CJ;Mendham,GE
我们测量了清醒、放松的受试者的总呼吸系统、肺阻力和胸壁阻力(RRS、RL和RCW)以及弹性阻力(ERS、EI和ECW)，并在潮气量(VT)为6%到18%VCAT恒定平均气道压的情况下对口腔施加正弦体积压力。此外，我们在较低的气道压力和较低的平均肺容量(VI)下重复测量最低的VT。RRS和RCW随呼吸频率(F)和VT的增加而减小，但RI与f和VT无关。ERS和ECW随f的增大而增大，随VT的增大而减小。Ei随f的增加略有增加，但不受VT的影响。我们得出结论：在呼吸幅度和频率的正常范围内，(1)如果平均肺容量不变，肺功能基本不变；(2)总呼吸系统功能的f和VT依赖是由胸壁引起的。
Wemeasured total respiratory system and lung and chest wall resistances (Rrs, Rl, and Rcw) and elastances (Ers, EI, and Ecw) in awake, relaxed human subjects during sinusoidal volume forcing at the mouth from 0.2 to 0.6 Hz with tidal volumes (VT) of 6 to 18% VCat constant mean airway pressure. In addition, we repeated measurements with the lowest VTat a lower airway pressure and therefore at a lower mean lung volume (VI). Rrs and Rcw decreased with increasing respiratory frequency (f) and VT, but RI was independent of f and VT. All resistances were higher at the lower VI. Ers and Ecw Increased with increasing f and decreased with increasing VT. EI increased slightly with Increasing f but was not affected by VT. All elastances tended to Increase at the lower VI. We conclude that In the normal range of breathing amplitude and frequency,(1) lung properties are nearly constant If mean lung volume does not change, and (2) f and VTdependencies of total respiratory system properties are caused by the chest wall.