SATTABACINS AND SATTAZOLINS - NEW BIOLOGICALLY-ACTIVE COMPOUNDS WITH ANTIVIRAL PROPERTIES EXTRACTED FROM A BACILLUS SP
SATTABACINS AND SATTAZOLINS - NEW BIOLOGICALLY-ACTIVE COMPOUNDS WITH ANTIVIRAL PROPERTIES EXTRACTED FROM A BACILLUS SP
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DOI：
10.7164/antibiotics.48.967
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发表时间：
1995-09-01
影响因子：
3.3
通讯作者：
SATTA, G
中科院分区：
文献类型：
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作者：
LAMPIS, G;DEIDDA, D;SATTA, G
从芽孢杆菌属中分离出一系列具有抗病毒特性的新化合物。菌株 B-60。它们被命名为sattabacin (1)、羟基sattabacin (2)、sattazolin (3) 和methylsattazolin (4)。通过乙酸乙酯萃取和硅胶柱分馏从发酵液中回收生物活性化合物。它们的抗病毒活性主要针对 1 型和 2 型单纯疱疹病毒。化合物 3 显示出对疱疹病毒感染细胞中蛋白质合成的选择性抑制。
A series of new compounds with antiviral properties were isolated from a Bacillus sp. strain B-60. They were named sattabacin (1), hydroxysattabacin (2), sattazolin (3) and methylsattazolin (4). The biologically active compounds were recovered from fermentation broth by ethyl acetate extraction and silica-gel column fractionation. Their antiviral activity was mainly expressed against the Herpes simplex viruses type 1 and 2. The compound 3 showed a selective inhibition of protein synthesis in Herpesvirus-infected cells.