Maternofetal transmission of AIDS: frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA.
Maternofetal transmission of AIDS: frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA.
复制标题
艾滋病母胎传播:人类胎儿 DNA 中人类免疫缺陷病毒 1 型核酸序列的频率。
DOI:
10.1093/infdis/166.4.699
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发表时间:
1992
期刊:
影响因子:
--
通讯作者:
Lyman,WD
中科院分区:
文献类型:
--
作者:
Soeiro,R;Rubinstein,A;Rashbaum,WK;Lyman,WD
Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-1)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.
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影响因子:
3.8
作者:
N. Halsey;R. Boulos;E. Holt;A. Ruff;J. Brutus;P. Kissinger;T. Quinn;JS Coberly;M. Adrien;C. Boulos;J. Marzouka;H. Davis;U. Auguste;F. Mode;F. Joseph;M. Fontaine;S. Dowell;G. Etheredge;JS Job
通讯作者:
JS Job
DOI:
--
发表时间:
1990
期刊:
影响因子:
--
作者:
D. Kellog;S. Kwok
通讯作者:
S. Kwok
DOI:
--
发表时间:
1983
期刊:
JAMA : the journal of the American Medical Association
影响因子:
--
作者:
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者:
Hollander,M
DOI:
--
发表时间:
1991
期刊:
The Lancet
影响因子:
--
作者:
A. Ades;M. Newell;C. Peckham
通讯作者:
C. Peckham
影响因子:
39.2
作者:
SCHNITTMAN, SM;GREENHOUSE, JJ;LANE, HC
通讯作者:
LANE, HC