Maternofetal transmission of AIDS: frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA.

Maternofetal transmission of AIDS: frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA.
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艾滋病母胎传播:人类胎儿 DNA 中人类免疫缺陷病毒 1 型核酸序列的频率。

DOI:
10.1093/infdis/166.4.699
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发表时间:
1992
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Lyman,WD
Lyman,WD
中科院分区:
--
文献类型:
--
作者:
Soeiro,R;Rubinstein,A;Rashbaum,WK;Lyman,WD

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Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-1)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.
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DOI: --
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期刊: JAMA : the journal of the American Medical Association
影响因子: --
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DOI: --
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影响因子: --
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影响因子: 39.2
作者:
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