Bacteria: A new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and Probiotics
Bacteria: A new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and Probiotics
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DOI：
10.1016/j.gtc.2007.07.012
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发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
Quigley, Eamonn M. M.
中科院分区：
文献类型：
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作者：
Quigley, Eamonn M. M.
肠易激综合征（IBS）可能是由于本地菌群和肠黏膜之间的功能失调相互作用，进而导致结肠黏膜的免疫激活。有人提出细菌过度生长是肠易激综合征症状发病的一个常见致病因素；其他人指出，有证据表明，原因源于结肠菌群中更微妙的质的变化。细菌过度生长可能不会被证明是最终被定义为肠易激综合征的主要因素。然而，短期抗生素或益生菌治疗似乎可以减轻肠易激综合征患者的症状。然而，从长远来看，安全性问题将有利于益生菌方法；这些药物的长期研究结果正在等待中。
Irritable bowel syndrome (IBS) may result from a dysfunctional interaction between the indigenous flora and the intestinal mucosa, which in turn leads to immune activation in the colonic mucosa. Some propose that bacterial overgrowth is a common causative factor in the pathogenesis of symptoms in IBS; others point to evidence suggesting that the cause stems from more subtle qualitative changes in the colonic flora. Bacterial overgrowth will probably prove not to be a major factor in what will eventually be defined as IBS. Nevertheless, short-term therapy with either antibiotics or probiotics seems to reduce symptoms among IBS patients. However, in the long term, safety issues will favor the probiotic approach; results of long-term studies with these agents are eagerly awaited.