Increased A20 mRNA Level in Peripheral Blood Mononuclear Cells is Associated With Immune Phases of Patients With Chronic Hepatitis B.
Increased A20 mRNA Level in Peripheral Blood Mononuclear Cells is Associated With Immune Phases of Patients With Chronic Hepatitis B.
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外周血单核细胞中 A20 mRNA 水平升高与慢性乙型肝炎患者的免疫阶段相关。
DOI：
10.1097/md.0000000000002428
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wang Kai
中科院分区：
文献类型：
--
作者：
Sun Yan-Yan;Fan Yu-Chen;Wang Na;Xia Harry Hua-Xiang;Xiao Xiao-Yan;Wang Kai
锌指蛋白A20是新发现的免疫应答负调控因子，在肝脏炎症中介导NF-κB信号通路。然而，A20在慢性乙型肝炎（CHB）患者的自然史中的作用尚未得到证实。在本研究中，我们旨在研究A20的动态表达，并确定A20在慢性乙型肝炎病毒感染进展中的潜在关联。
The zinc finger protein A20 is a newly identified negative regulator of immune response and mediates signal pathway of NF-κB in liver inflammation. However, the role of A20 in the natural history of patients with chronic hepatitis B (CHB) has not been demonstrated. In this present study, we aimed to investigate the dynamic expression of A20 and determine the potential association of A20 in the progression of chronic hepatitis B virus infection.