Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study.
Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study.
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DOI：
10.1002/dad2.12263
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
HABLE Study Team
中科院分区：
文献类型：
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作者：
King KS;Vintimilla RM;Braskie MN;Wei K;Hall JR;Borzage M;Johnson LA;Yaffe K;Toga AW;O'Bryant SE;HABLE Study Team
在血管危险因素中，我们假设西班牙裔糖尿病患病率的增加与更大的白色高信号（WMH）体积相关，这可能导致认知能力下降。共有1318例受试者（60%女性; 49%西班牙裔，51%非西班牙裔白色;年龄66.2 ± 8.9岁）接受了临床评价和脑磁共振成像（MRI）。WMH体积与年龄、性别和种族的相关性进行了评估，然后在选择性回归模型中与血管危险因素进行了评估。WMH体积随着年龄的增长（P <0.0001），西班牙裔（P = 0.02）和女性（P = 0.049）而增加。年龄、舒张压、高血压病史、糖化血红蛋白（HbA 1c）、白色血细胞计数和红细胞压积是预测WMH体积的最佳指标（所有指标均P <0.01）。在西班牙裔人群中，HbA 1c升高与WMH体积增大相关（参数估计值为0.08 ± 0.02，P <0.0001），但在非西班牙裔白人人群中则与WMH体积增大无关（参数估计值为0.02 ± 0.04，P = 0.5）。西班牙裔的WMH体积更大，这可能部分解释为西班牙裔而非非西班牙裔白人中与HbA 1c升高相关的WMH体积增加。
Among vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline. A total of 1318 participants (60% female; 49% Hispanic, 51% non‐Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model. WMH volume was greater with older age (P < .0001), Hispanic ethnicity (P = .02), and female sex (P = .049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit (P < .01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, P < .0001) but not non‐Hispanic Whites (parameter estimate 0.02 ± 0.04, P = .5). WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non‐Hispanic Whites.