Serum zinc level in depressed patients during zinc supplementation of imipramine treatment.
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment.
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DOI：
10.1016/j.jad.2010.04.024
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发表时间：
2010-11
影响因子：
6.6
通讯作者：
M. Siwek;D. Dudek;M. Schlegel-Zawadzka;A. Morawska;W. Piekoszewski;W. Opoka;A. Zięba;Andrzej Pilc
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文献类型：
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作者：
M. Siwek;D. Dudek;M. Schlegel-Zawadzka;A. Morawska;W. Piekoszewski;W. Opoka;A. Zięba;Andrzej Pilc
背景：重复性抑郁症与血锌浓度降低有关，有效的抗抑郁药物治疗可提高血锌浓度。一些临床研究表明，血液中锌水平的变化可能是抑郁症的一个标志。方法采用安慰剂对照的双盲研究方法，对60例符合DSM-IV抑郁症诊断标准的患者(年龄18-55岁，女性40例，男性20例)进行丙咪嗪治疗的补锌治疗。此外，还招募了25名健康志愿者(女性16名，男性9名)。结果：1)抑郁症患者的血清锌水平显著低于健康志愿者(降低22%)；2)在丙咪嗪治疗期间，所有患者的锌浓度均逐渐升高；(3)耐药患者的锌浓度低于非耐药患者(14%)；4)补锌患者的锌浓度高于安慰剂患者。6)在丙咪嗪治疗12周时，蒙哥马利-阿斯伯格抑郁量表与血清锌水平呈显著负相关，缓解期患者血清锌水平也随之升高。
BACKGROUNDRecurrent major depression is associated with decreased blood zinc concentrations that may be increased by effective antidepressant therapy. Some clinical investigations point to alterations of the zinc level in blood as a potential marker of depression.METHODSA placebo-controlled, double blind study of zinc supplementation to imipramine therapy was conducted on sixty patients fulfilling the DSM-IV criteria for major depression (18–55years old, 40 females, 20 males). Moreover, a group of 25 healthy volunteers was recruited (16 females, 9 males). Blood samples were drawn for the assay of serum zinc once from the control subjects and four times (before, and then 2, 6 and 12weeks after the beginning of treatment) from the depressed subjects.RESULTSWe report that: 1) the serum zinc level was significantly lower (by 22%) in depressed patients than in healthy volunteers, 2) all groups demonstrated a gradual increase in zinc concentrations over the period of imipramine treatment with or without zinc supplementation, 3) treatment-resistant patients demonstrated lower concentrations of zinc (by 14%) than treatment-non-resistant patients, 4) zinc concentrations were higher in zinc-supplemented patients than in placebo-supplemented patients, 5) zinc supplementation increased zinc concentrations over the period of treatment, and 6) at a 12-week imipramine treatment, a significant negative correlation was demonstrated between the Montgomery–Asberg Depression Rating Scale and the serum zinc level together with a concomitant increase in serum zinc in patients in remission.CONCLUSIONSSerum zinc is a state marker of depression.