EFFECTS OF LAMININ ON FUNCTIONAL REINNERVATION OF TARGET ORGANS BY REGENERATING AXONS
EFFECTS OF LAMININ ON FUNCTIONAL REINNERVATION OF TARGET ORGANS BY REGENERATING AXONS
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DOI：
10.1097/00001756-199101000-00009
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发表时间：
1991-01-01
期刊：
影响因子：
1.7
通讯作者：
FURCHT, LT
中科院分区：
文献类型：
--
作者：
NAVARRO, X;KENNEDY, WR;FURCHT, LT
在小鼠爪中，在切断坐骨神经并通过用胶原导管（有和没有层粘连蛋白涂层）进行神经移植修复后，研究了汗腺、骨骼肌和皮肤的神经再生。术后32天，毛果芸香碱激活的汗腺再次出现，数量增加到对照计数的67%。在第39天从骨间肌记录肌肉动作电位（坐骨神经刺激期间）。电位幅值增加到对照组的30%。在约34天观察到从针刺到爪的第一次撤回反应，反应评分增加到对照的66%。在任何测试间隔，对照组和添加层粘连蛋白的组之间没有显著差异。
REINNERVATION of sweat glands, skeletal muscle and skin was studied in the mouse paw after section of the sciatic nerve and repair by entubulation with collagen conduits, with and without a coating of laminin. After operation, sweat glands activated by pilocarpine reappeared at 32 days and increased in number to 67% of control counts. Muscle action potentials (during sciatic nerve stimulation) were recorded from the interosseus muscle at 39 days. The potential amplitudes increased to 30% of controls. The first withdrawal response from pin prick to the paw was observed at about 34 days, the response score increasing to 66% of control. There were no significant differences at any test interval between the control group and the group with laminin added.