Overexpression of Transforming Growth Factor-pl mRNA Is Associated With Up-Regulation of Glomerular Tenascin and Laminin Gene Expression in Nonobese Diabetic Mice1
Overexpression of Transforming Growth Factor-pl mRNA Is Associated With Up-Regulation of Glomerular Tenascin and Laminin Gene Expression in Nonobese Diabetic Mice1
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发表时间：
2005
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通讯作者：
Chih-wei;Yang;Masakazu;Hattori;Helen;Vlassara;Ci-Jiang;He;Michael;-A.;Carome;Eiji;Yamato;Sharon;Elliot;Gary;E. Striker;Liliane;J. Striker;-S.;E. G.;Striker;J. L.
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作者：
Chih-wei;Yang;Masakazu;Hattori;Helen;Vlassara;Ci-Jiang;He;Michael;-A.;Carome;Eiji;Yamato;Sharon;Elliot;Gary;E. Striker;Liliane;J. Striker;-S.;E. G.;Striker;J. L.
Am.非肥胖糖尿病（NOD）小鼠自发地发展免疫介导的胰岛素依赖性糖尿病和肾病，这为研究糖尿病肾小球硬化模型中的早期分子事件提供了机会。通过逆转录-竞争性聚合酶的使用，在显微切割的肾小球中检测了编码生长因子和细胞外基质的几种基因的表达
Am. Soc. ABSTRACT Nonobese diabetic (NOD) mice spontaneously develop immune-mediated insulin-dependent diabetes mellitus and nephropathy, providing an opportunity to study the early molecular events in a model of diabetic glomerulosclerosis. The expression of several genes coding for growth factors and extracellular matrix was examined in microdissected glomeruli, by the use of reverse transcription-competitive polymerase