[Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion].
[Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion].
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静脉注射兰索拉唑对急性胃黏膜病变及胃酸分泌的影响
DOI：
10.1254/fpj.108.6_333
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Satoh
中科院分区：
文献类型：
--
作者：
N. Inatomi;I. Murakami;S. Asano;I. Inada;H. Satoh
在大鼠中研究了兰索拉唑静脉给药对胃粘膜病变、胃出血和胃酸分泌的影响，并与奥美拉唑、法莫替丁和雷尼替丁进行了比较。兰索拉唑可抑制水浸应激或阿司匹林诱导的大鼠胃粘膜病变形成，ID 50值分别为0.26和0.99 mg/kg，还可抑制失血性休克或水浸应激诱导的胃出血，ID 50值分别为0.46和1.22 mg/kg。兰索拉唑在抑制胃粘膜病变和出血性休克或应激诱导的出血方面比奥美拉唑、法莫替丁和雷尼替丁更有效。法莫替丁和雷尼替丁对水浸应激诱导的胃出血的抑制作用可忽略不计。兰索拉唑强烈抑制大鼠水浸应激刺激的酸分泌，而法莫替丁和雷尼替丁未显示出强效抑制作用。这些结果表明，兰索拉唑通过抑制胃酸分泌对胃粘膜病变的形成和胃出血具有显著的抑制作用，并且在抑制应激性胃出血方面上级组胺H2受体拮抗剂。
The effects of lansoprazole given intravenously on gastric mucosal lesions, gastric bleeding and acid secretion were investigated in rats in comparison with those of omeprazole, famotidine and ranitidine. Lansoprazole inhibited the formation of gastric mucosal lesions in rats induced by water-immersion stress or aspirin with ID50 values of 0.26 and 0.99 mg/kg, respectively, and also inhibited gastric bleeding induced by hemorrhagic shock or water-immersion stress with ID50 values of 0.46 and 1.22 mg/kg, respectively. Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding. Famotidine and ranitidine showed negligible inhibition of water-immersion stress-induced gastric bleeding. Lansoprazole strongly inhibited water-immersion stress-stimulated acid secretion in rats, whereas famotidine and ranitidine did not show a potent inhibitory effect. These results indicate that lansoprazole exerts prominent inhibitory actions against the formation of gastric mucosal lesions and gastric bleeding by inhibiting acid secretion, and they show that it is superior to histamine H2-receptor antagonists in inhibiting stress-induced gastric bleeding.