HYPERGLYCEMIA ENLARGES INFARCT SIZE IN CEREBROVASCULAR OCCLUSION IN CATS
HYPERGLYCEMIA ENLARGES INFARCT SIZE IN CEREBROVASCULAR OCCLUSION IN CATS
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DOI：
10.1161/01.str.19.5.623
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发表时间：
1988-05-01
期刊：
影响因子：
8.3
通讯作者：
SCHOOLFIELD, L
中科院分区：
文献类型：
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作者：
DECOURTENMYERS, G;MYERS, RE;SCHOOLFIELD, L
我们研究了血糖浓度对猫大脑中动脉闭塞后脑梗塞范围的影响。禁食48h后分别给予生理盐水1h和8h(n=8)，10%葡萄糖溶液1h和6h加生理盐水2h(n=8)，10%葡萄糖1h加生理盐水8h(n=5)。对存活2周后处死的19只猫进行形态计量学的脑梗塞面积测定。8只正常血糖和11只高血糖猫的大脑中动脉区域分别有10.2+/-3.4%和29.5+/-6.5%(平均+/-扫描电子显微镜)受累(p<0.02)。两个高血糖组的猫显示出相似大小的梗塞。然而，在8只患有闭塞前和闭塞后高血糖的猫中，有2只(25%)在闭塞后8小时和24小时死亡，并伴有整个大脑中动脉区域的梗塞、明显的半球水肿和脑干受压。我们的结果表明，大血管闭塞时的血糖浓度影响卒中的预后。
We investigated the influence of serum glucose concentration on infarct size following middle cerebral artery occlusion in cats. These animals were deprived of food for 48 hours and infused with 1) saline for 1 hour before and 8 hours after occlusion (n = 8), 2) 10% glucose solution for 1 hour before and 6 hours after occlusion and saline for 2 additional hours (n = 8), or 3) 10% glucose for 1 hour before and saline for 8 hours after occlusion (n = 5). Nineteen cats killed after 2 weeks' survival were subjected to morphometric infarct size determinations. Eight normoglycemic and 11 hyperglycemic cats exhibited infarcts affecting 10.2 +/- 3.4% and 29.5 +/- 6.5% (mean +/- SEM) of their middle cerebral artery territories, respectively (p less than 0.02). Cats of the two hyperglycemic groups showed similarly sized infarcts. However, two of eight (25%) of cats with preocclusion and postocclusion hyperglycemia died 8 and 24 hours after occlusion with infarction of the entire middle cerebral artery territory, marked hemispheral edema, and brainstem compression. Our results demonstrate that serum glucose concentration at the time of large cerebral vessel occlusion influences stroke outcome.