Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression.
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression.
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DOI：
10.1016/j.biopsych.2016.09.007
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发表时间：
2017-04-15
影响因子：
10.6
通讯作者：
Lobo MK
中科院分区：
文献类型：
--
作者：
Francis TC;Lobo MK
腹侧纹状体（nucleus numbens-NAc）及其在情绪、奖励和动机中的作用一直是重要研究的焦点。尽管有这种兴趣，很少有工作已经解决了细胞类型的具体区别中多刺神经元（MSN），在NAc和背侧纹状体的主要投射神经元，和他们的功能有关的压力和抑郁症。以前的工作证明了多巴胺1受体（D1）和多巴胺2受体（D2）MSN亚型在压力的抑郁样结果中的相反作用，特别是在重复神经元刺激和兴奋性传递方面。然而，其作用机制仍不清楚。我们讨论了潜在的机制，MSN亚型功能促进二分的行为结果，由于细胞可塑性，亚细胞信号通路和基因表达的差异。这篇综述的目的是解决我们目前的理解有关的作用，神经核MSN亚型在压力相关的抑郁行为和推测目前理解的机制如何有助于控制活动的MSNs的因素。
The ventral striatum (nucleus accumbens- NAc) and its role in mood, reward, and motivation has been the focus of significant research. Despite this interest, very little work has addressed cell-type specific distinctions in medium spiny neurons (MSNs), the main projection neurons in the NAc and dorsal striatum, and their function in relation to stress and depression. Previous work demonstrates opposing roles for Dopamine 1 receptor (D1) and dopamine 2 receptor (D2) MSN subtypes, in depression-like outcomes to stress, particularly in regards to repeated neuronal stimulation and excitatory transmission. Yet the mechanisms of action are still unknown. We discuss potential mechanisms by which MSN subtype function promotes dichotomous behavioral outcomes due to differences in cellular plasticity, subcellular signaling pathways, and genetic expression. This review aims to address our current understanding about the role of nucleus accumbens MSN subtypes in stress-related depression behavior and speculates on how currently understood mechanisms contribute to factors which control activity of MSNs.