Thermomechanical properties of PEGDA and its co-polymers
Thermomechanical properties of PEGDA and its co-polymers
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DOI：
10.1515/cdbme-2018-0161
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发表时间：
2018-09
影响因子：
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通讯作者：
Natalia Rekowska;D. Arbeiter;J. Konasch;Alexander Riess;R. Mau;T. Eickner;H. Seitz;N. Grabow;M. Teske
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文献类型：
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作者：
Natalia Rekowska;D. Arbeiter;J. Konasch;Alexander Riess;R. Mau;T. Eickner;H. Seitz;N. Grabow;M. Teske
摘要目前的研究活动集中在个性化，舒适和安全的产品，全身或局部药物应用于患者。聚（乙二醇）二丙烯酸酯作为药物递送材料特别令人感兴趣，因为它显示出适当的生物学性质，例如亲水性和低毒性。此外，作为一种容易光聚合的化合物，它也可以用于使用不同的技术，如立体光刻生产支架。尽管它经常被用作生物材料或作为共聚物在许多光聚合物系统的药物输送，热机械分析和基本的了解是罕见的。因此，我们研究了纯PEGDA及其与1，3-丁二醇二丙烯酸酯或季戊四醇三丙烯酸酯的共聚物的拉伸应力和玻璃化转变温度，作为光引发剂（PI）或丙烯酸酯浓度的函数。此外，我们证明了洗涤过程降低了拉伸应力值。我们表明，通过与这些组成的PEGDA的手段，它是可能的影响样品的热机械性能。我们的结果表明，PI浓度对热机械性能没有明显的影响。然而，存在单体浓度的影响。因此，它应该是可能的，以修改药物释放曲线在未来的实验。
Abstract Current research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare. Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.