Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women
Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women
复制标题
DOI：
10.1093/aje/kwq089
复制
发表时间：
2010-07-15
影响因子：
5
通讯作者：
Karlson, Elizabeth W.
中科院分区：
文献类型：
--
作者：
Costenbader, Karen H.;Kang, Jae Hee;Karlson, Elizabeth W.
抗氧化剂可以通过对抗氧化应激来防止类风湿性关节炎或系统性红斑狼疮的发展。作者在1980年至2004年的护士健康研究和护士健康研究II队列中，在184，643名美国妇女中确定并确认了类风湿性关节炎和系统性红斑狼疮的事件病例。半定量食物频率问卷评估了食物和补充剂中维生素A、C和E以及α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素、叶黄素和玉米黄质的摄入量。作者通过计算“血浆铁还原能力”评分来检查总抗氧化剂摄入量，这是一种基于抗氧化剂将三价铁还原为二价铁来量化食物总抗氧化作用的新方法。使用了累积更新的总能量调整膳食摄入量。每种营养素的摄入量与类风湿性关节炎和系统性红斑狼疮的发病率之间的关系在年龄调整和考克斯比例风险模型中进行了研究，调整了混杂因素。使用随机效应模型对队列结果进行荟萃分析。作者确定了787例类风湿性关节炎和192例系统性红斑狼疮病例，这些病例有前瞻性的饮食信息。在这些大规模的前瞻性女性队列中，抗氧化剂摄入与发生类风湿性关节炎或系统性红斑狼疮的风险无关。
Antioxidants may protect against development of rheumatoid arthritis or systemic lupus erythematosus by combating oxidative stress. The authors identified and confirmed incident cases of rheumatoid arthritis and systemic lupus erythematosus among 184,643 US women followed in the Nurses' Health Study and Nurses' Health Study II cohorts in 1980-2004. Semiquantitative food frequency questionnaires assessed intakes of vitamins A, C, and E and alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin from foods and supplements. The authors examined total antioxidant intake by calculating a "ferric-reducing ability of plasma" score, a new method for quantifying the total antioxidant effect of a food based on the reduction of ferric to ferrous iron by antioxidants. Cumulative updated total energy-adjusted dietary intakes were used. Associations between intake of each nutrient and incident rheumatoid arthritis and systemic lupus erythematosus were examined in age-adjusted and Cox proportional hazards models, adjusted for confounders. Results from the cohorts were pooled meta-analytically by using random-effects models. The authors identified 787 incident rheumatoid arthritis cases and 192 systemic lupus erythematosus cases for whom prospective dietary information was available. In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus.