ONTOGENY OF SUSCEPTIBILITY TO EXPERIMENTAL FEBRILE SEIZURES IN RATS
ONTOGENY OF SUSCEPTIBILITY TO EXPERIMENTAL FEBRILE SEIZURES IN RATS
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DOI：
10.1002/dev.420210307
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发表时间：
1988-04-01
影响因子：
2.2
通讯作者：
DIAZ, J
中科院分区：
文献类型：
--
作者：
HJERESEN, DL;DIAZ, J
使用微波热疗 (MHT) 进行了两项实验，以在有限数量的朗-埃文斯幼鼠中诱导癫痫发作。热性惊厥的 MHT 模型消除了先前该疾病动物模型中固有的几种方法学并发症。在实验 1 中，产后第 11、13、15 或 17 天，用 MHT 对幼鼠进行高温治疗或进行假辐射。结果表明，随着年龄的增长，癫痫易感性显着下降。在实验 2 中，大鼠在产后第 11、13、15 或 17 天接受单次或多次高温治疗。结果表明，由于既往癫痫病史，癫痫发作的易感性增加。在这两个实验中，直肠温度升高 1 至 3 度都会诱发癫痫发作。 C. 结果与热性惊厥的许多临床特征相似，并论证了 MHT 模型的功效。
Two experiments were conducted using microwave hyperthermia (MHT) to induce seizures among limited numbers of Long-Evans rat pups. The MHT model of febrile seizures eliminates several methodological complications inherent in previous animal models of the disorder. In Experimental 1, rat pups were rendered hyperthermic with MHT or were sham-irradiated on Days 11, 13, 15 or 17 postpartum. The results indicate a statistically significant decline in seizure susceptibility with age. In Experiment 2, rats were subjected to either single or multiple hyperthermic episodes on Days 11, 13, 15, or 17 postpartum. The results indicate an increase in susceptibility to seizures attributable to prior seizure history. In both experiments, seizures were induced with increases in rectal temperature of 1 to 3.degree. C. The results parallel many clinical features of febrile seizures and argue the efficacy of the MHT model.