Process-specific prefrontal contributions to episodic encoding and retrieval of tastes: A functional NIRS study
Process-specific prefrontal contributions to episodic encoding and retrieval of tastes: A functional NIRS study
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DOI：
10.1016/j.neuroimage.2010.08.016
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发表时间：
2011-01-15
期刊：
影响因子：
5.7
通讯作者：
Dan, Ippeita
中科院分区：
文献类型：
--
作者：
Okamoto, Masako;Wada, Yuji;Dan, Ippeita
记忆子过程、编码和检索的神经基础已在功能神经影像学研究中得到广泛研究。然而，味觉记忆的皮质基质是我们情景记忆的重要组成部分，但在人类中却很少被探索。此前，我们使用功能性近红外光谱（fNIRS）发现外侧前额叶皮层（LPFC）的激活与味觉编码相关。当前研究中使用的方法允许在参与者以直立姿势品尝液体味觉刺激时进行大脑监测。这里。使用相同的系统，我们检查了 28 名健康志愿者在味觉记忆编码和检索过程中的 LPFC 活动。检索和闭眼休息条件之间的对比揭示了双侧 LPFC 的激活。这种激活明显大于双侧额极和右背 LPFC 区域的编码激活，特别是在右半球（N = 28，P < 0.05，FDR 校正），表现出右半球优势。我们的研究结果与半球编码/检索不对称（HERA）模型一致，该模型提出了特定于过程的前额叶对记忆功能的贡献。 (C) 2010 Elsevier Inc. 保留所有权利。
The neural basis of memory subprocesses, encoding and retrieval, have been extensively examined in functional neuroimaging studies. However, the cortical substrates of taste memory, which form an important part of our episodic memory, have rarely been explored in humans. Previously, we have used functional near-infrared spectroscopy (fNIRS) and found activation of the lateral prefrontal cortex (LPFC) related to taste encoding. The method used in the current study allowed brain monitoring while participants tasted liquid taste-stimuli in upright positions. Here. using the same system, we examined the LPFC activity of 28 healthy volunteers during both the encoding and the retrieval of taste memory. The contrast between the retrieval and eyes-closed-resting conditions revealed activation in the bilateral LPFC. This activation was significantly larger than that for encoding in the bilateral frontopolar and right dorso-LPFC regions, particularly in the right hemisphere (N = 28, P < 0.05, FDR corrected), exhibiting right hemispheric dominance. Our findings are in line with the hemispheric encoding/retrieval asymmetry (HERA) model, which proposes a process-specific prefrontal contribution to memory function. (C) 2010 Elsevier Inc. All rights reserved.