Mapping of the genetically independent chicken major histocompatibility complexes B-@ and RFP-Y-@ to the same microchromosome by two-color fluorescent in situ hybridization
Mapping of the genetically independent chicken major histocompatibility complexes B-@ and RFP-Y-@ to the same microchromosome by two-color fluorescent in situ hybridization
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DOI：
10.1159/000134445
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Vignal, A
中科院分区：
文献类型：
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作者：
Fillon, V;Zoorob, R;Vignal, A
鸡 MHC 由两个遗传独立的基因复合体 B-@ 和 RFP-Y-@ 组成。先前的研究表明 B-@ 复合物定位在一个小的微染色体上。通过使用双色荧光原位杂交，我们证明了 RFP-Y-@ 复合物定位于同一染色体。两个基因座之间的重组热点可能是它们独立分离的原因。
The chicken MHC is organized in two genetically independent gene complexes B-@ and RFP-Y-@. Previous studies have shown the localization of the B-@ complex on a small microchromosome. By using two-color fluorescent in situ hybridization, we demonstrate the localization of the RFP-Y-@ complex to the same chromosome. A recombination hot spot between the two loci might account for their independent segregation.