Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.
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DOI：
10.3390/antiox4030513
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发表时间：
2015-07-09
期刊：
影响因子：
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通讯作者：
Morita M
中科院分区：
文献类型：
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作者：
Azuma T;Yamane M;Ekuni D;Kawabata Y;Kataoka K;Kasuyama K;Maruyama T;Tomofuji T;Morita M
氧化应激参与牙周炎的发病机制。通过饮用富氢水（HW）来减少氧化应激可能对牙周健康有益。在这项初步研究中，我们比较了非手术牙周治疗与不饮用HW对牙周炎的影响。将13例牙周炎患者（女3例，男10例）分为对照组（n = 6）和HW组（n = 7）。在HW组，参与者每天食用HW 4-5次，持续8周。在两到四周，所有的参与者都接受了非手术牙周治疗。在基线、2周、4周和8周进行口腔检查，并在这些时间点采集血清以评估氧化应激。在基线时，对照组和HW组的牙周状况没有显著差异。在第2周、第4周和第8周，HW组在探查袋深度和临床附着水平上均优于对照组（p < 0.05）。与基线相比，HW组在第四周时血清总抗氧化能力水平也有所提高（p < 0.05）。饮用HW可增强牙周非手术治疗的效果，从而改善牙周炎。
Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The control group (n = 6) or the HW group (n = 7). In the HW group, participants consumed HW 4–5 times/day for eight weeks. At two to four weeks, all participants received non-surgical periodontal treatment. Oral examinations were performed at baseline, two, four and eight weeks, and serum was obtained at these time points to evaluate oxidative stress. At baseline, there were no significant differences in periodontal status between the control and HW groups. The HW group showed greater improvements in probing pocket depth and clinical attachment level than the control group at two, four and eight weeks (p < 0.05). The HW group also exhibited an increased serum level of total antioxidant capacity at four weeks, compared to baseline (p < 0.05). Drinking HW enhanced the effects of non-surgical periodontal treatment, thus improving periodontitis.