Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis
Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis
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DOI：
10.1016/j.atherosclerosis.2007.04.046
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发表时间：
2008-01-01
期刊：
影响因子：
5.3
通讯作者：
Foeger, Bernhard
中科院分区：
文献类型：
--
作者：
Schgoer, Wilfried;Mueller, Thomas;Foeger, Bernhard
目的：磷脂转移蛋白（PLTP）促进胆固醇从细胞流出，血管内HDL重塑和维生素E和内毒素的转移。在人类中，PUP与动脉粥样硬化的关系尚不清楚。然而，强冠状动脉危险因素如肥胖、糖尿病、吸烟和炎症会增加活性PUP的循环水平。本横断面研究的目的是分析PLTP与外周动脉疾病的关系，广泛性动脉粥样硬化的标志物，独立于潜在的混杂因素，如肥胖，糖尿病和smoking.Methods：我们进行了一项病例对照研究，153例有症状的外周动脉疾病（PAD）和208对照无血管疾病。排除吸烟者和糖尿病患者。A脂蛋白非依赖性测定用于测量循环生物活性PLTP和ELISA利用单克隆抗体被用来分析PLTP mass.Results：PUP活性显着降低PAD患者5.5（4.6-6.4）（中位数（第25 - 75百分位数））与5.9（5.1-6.9）μ mol/mL/h在控制（p = 0.001）。相比之下，PAD患者的PUP质量为8.5 μ g/mL（7.3-9.5），对照组为8.3 μ g/mL（6.9-9.7）（p = 0.665）。多因素Logistic回归分析显示PLTP活性与PAD的存在独立相关。PLTP活性相似的患者和无降脂药物（p = 0.396）。结论：我们的研究结果表明，在非糖尿病，非吸烟受试者低，而不是高PLTP活性是一个标志物的存在外周动脉疾病和高活性和低活性形式之间的分布PUP可能会受到损害动脉粥样硬化。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Phospholipid transfer protein (PLTP) facilitates cholesterol efflux from cells, intravascular HDL remodelling and transfer of vitamin E and endotoxin. In humans, the relationship of PUP to atherosclerosis is unknown. However, strong coronary risk factors like obesity, diabetes, cigarette smoking and inflammation increase circulating levels of active PUP. The aim of the present, cross-sectional study was to analyze the relationship of PLTP to peripheral arterial disease, a marker of generalized atherosclerosis, independently of potentially confounding factors like obesity, diabetes and smoking.Methods: We performed a case control study in 153 patients with symptomatic peripheral arterial disease (PAD) and 208 controls free of vascular disease. Smokers and patients with diabetes mellitus were excluded. A lipoprotein-independent assay was used for measurement of circulating bioactive PLTP and an ELISA utilizing a monoclonal antibody was used to analyze PLTP mass.Results: PUP activity was significantly decreased in patients with PAD 5.5 (4.6-6.4)(median (25th-75th percentile)) versus 5.9 (5.1-6.9) mu mol/mL/h in controls (p = 0.001). In contrast, PUP mass was similar in patients with PAD 8.5 mu g/mL (7.3-9.5) and in controls 8.3 mu g/mL (6.9-9.7) (p = 0.665). Multivariate logistic regression analysis revealed that PLTP activity is independently associated with the presence of PAD. PLTP activity was similar in patients with and without lipid-lowering drugs (p = 0.396).Conclusion: Our results show that in non-diabetic, non-smoking subjects low rather than high PLTP activity is a marker for the presence of peripheral arterial disease and that distribution of PUP between high-activity and low-activity forms may be compromised in atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.