Persistence of a sexually transmitted highly resistant HIV-1:: pol quasispecies evolution over 33 months in the absence of treatment
Persistence of a sexually transmitted highly resistant HIV-1:: pol quasispecies evolution over 33 months in the absence of treatment
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DOI：
10.1097/qad.0b013e328010ac6f
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发表时间：
2006-11-14
期刊：
影响因子：
3.8
通讯作者：
Kuecherer, Claudia
中科院分区：
文献类型：
--
作者：
Neifer, Stefan;Somogyi, Sybille;Kuecherer, Claudia
在一个链接的传播链中，性传播的多重耐药HIV-1的演变被跟踪了33个月，以评估其在没有治疗的情况下持续存在的潜力。多重耐药的HIV在逆转录酶中缓慢地回复到野生型（位置44、67、74、118），使得病毒仅对拉米夫定/恩曲他滨敏感。具有复制能力的耐药性艾滋病毒的持续存在增加了其进一步传播的可能性，并加强了对新感染患者进行耐药性检测的重要性。
The evolution of a sexually transmitted multiresistant HIV-1 in a linked transmission chain was followed for 33 months to assess its potential to persist in the absence of treatment. The multiresistant HIV reverted slowly to wild type in reverse transcriptase (positions 44, 67, 74, 118) rendering the virus only susceptible to lamivudine/emtricitabine. Persistence of the replication-competent resistant HIV increases its potential to spread further and strengthens the importance of resistance testing in newly infected patients.