Hepatosplenic gamma delta T-cell lymphoma associated with hepatitis B virus infection.
Hepatosplenic gamma delta T-cell lymphoma associated with hepatitis B virus infection.
复制标题
与乙型肝炎病毒感染相关的肝脾γδT细胞淋巴瘤。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Toshio Matsumoto
中科院分区：
文献类型：
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作者：
Shuji Ozaki;Koji Ogasahara;Masaaki Kosaka;T. Inoshita;Shingo Wakatsuki;Hisanori Uehara;Toshio Matsumoto
B型肝炎病毒（HBV）感染与肝细胞和造血系统恶性肿瘤的发生有关。我们描述了一个慢性肝炎B谁开发肝脾γ δ T细胞淋巴瘤的患者。一位45岁女性在慢性B型肝炎期间出现明显的肝脾肿大和肝功能衰竭。外周血检查显示57%的异常淋巴细胞表达γ δ T细胞受体。肿瘤细胞的细胞遗传学分析显示异常核型：在所有检查的20个中期分裂相中，47，XX，-13，+2mar。通过Southern印迹分析证明T细胞受体基因的克隆重排，显示肿瘤细胞的单克隆扩增。肝活检标本显示汇管区纤维化和肿瘤细胞的窦状隙浸润。HBV感染通过血清中IgG抗HBc和抗HBs抗体的存在来记录。虽然通过聚合酶链反应分析在肿瘤细胞中未检测到HBV-DNA，但有可能γ δ T细胞对HBV感染的应答增殖在肝脾γ δ T细胞淋巴瘤的发病机制中发挥作用。
Hepatitis B virus (HBV) infection has been implicated in the development of hepatocellular and hematopoietic malignancies. We describe a patient with chronic hepatitis B who developed hepatosplenic gamma delta T-cell lymphoma. A 45-year-old woman presented with marked hepatosplenomegaly and hepatic failure during the course of chronic hepatitis B. Peripheral blood examination revealed 57% abnormal lymphoid cells which expressed the gamma delta T-cell receptor. The cytogenetic analysis of tumor cells showed an abnormal karyotype; 47, XX, -13, +2mar in all 20 metaphases examined. A clonal rearrangement of the T-cell receptor genes was demonstrated by Southern blot analysis, showing monoclonal expansion of tumor cells. A liver biopsy specimen showed fibrosis of the portal areas and sinusoidal infiltration of tumor cells. HBV infection was documented by the presence of IgG anti-HBc and anti-HBs antibodies in serum. Although HBV-DNA was not detected in tumor cells by polymerase chain reaction analysis, there is a possibility that proliferation of gamma delta T cells in response to HBV infection played a role in the pathogenesis of hepatosplenic gamma delta T-cell lymphoma.